edited by Sylke Müller, Rachel Cerdan, and Ovidiu Radulescu
مشخصات ظاهری
نام خاص و کميت اثر
1 online resource.
فروست
عنوان فروست
Drug discovery in infectious diseases
يادداشت کلی
متن يادداشت
Includes index
یادداشتهای مربوط به مندرجات
متن يادداشت
Identification and Validation of New Drugs and Targets. Discovery of the Mechanism of Action of Novel Compounds That Target Unicellular Eukaryotic Parasites / Daniela Begolo, Christine Clayton -- Antiparasitics from Algae / Stefan Ringgeler, Barbara Kappes -- Contribution of Natural Products to Drug Discovery in Tropical Diseases / Frederick Annang, Olga Genilloud, Francisca Vicente -- Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites / Tina Weber, Paul M Selzer -- Trypanosomal Cysteine Peptidases: Target Validation and Drug Design Strategies / Elany Barbosa Silva, Glaecia Aparecida Nascimento Pereira, Rafaela Salgado Ferreira -- Potential of Pyrimidine Metabolism for Antitrypanosomal Drug Discovery / Maria Valente, Antonio E Vidal, Dolores Gonzalez Pacanowska -- Phosphatidylcholine and Phosphatidylethanolamine Biosynthesis Pathways in Plasmodium / Ewelina Guca, Alicia Contet, Henri J Vial, Kai Wengelnik, Rachel Cerdan -- Immunophilins as Possible Drug Targets in Apicomplexan Parasites / Alessandra Bianchin, Anthony J Chubb, Angus Bell -- Targeting the Atg8 Conjugation Pathway for Novel Anti-Apicomplexan Drug Discovery / Alexia S Miller, Jurgen Bosch -- Turnover of Glycosomes in Trypanosomes : Perspectives for Drug Discovery / Ana Brennand, Eva Rico, Melisa Gualdron-Lopez, Paul AM Michels -- Glideosome of Apicomplexans as a Drug Target / Lauren E Boucher, Jurgen Bosch -- N-Myristoyltransferase as a Target for Drug Discovery in Malaria / James A Brannigan, Anthony J Wilkinson -- Metabolomics in Drug and Target Discovery. Methods to Investigate Metabolic Systems in Trypanosoma / Maria Fatarova, Florian Bellvert, Edern Cahoreau, Frederic Bringaud, Jean-Charles Portais -- The Role of Metabolomics in Antiparasitic Drug Discovery / Carlo R Giannangelo, Katherine M Ellis, Anna E Sexton, Daniel Stoessel, Darren J Creek -- The Importance of Targeting Lipid Metabolism in Parasites for Drug Discovery / Simon A Young, Matthew D Roberts, Terry K Smith -- Carbon Metabolism of Plasmodium falciparum / Marco Biddau, Sylke Muller -- Gene Expression and Its Regulation : A Promising Research Area for Drug Discovery. Epigenetic Gene Regulation: Key to Development and Survival of Malaria Parasites / Sabine Anne-Kristin Fraschka, Richard Bartfai -- Mechanisms Regulating Transcription in Plasmodium falciparum as Targets for Novel Antimalarial Drugs / Evelien M Bunnik, Karine G Le Roch -- Aminoacyl t-RNA Synthetases as Antimalarial Drug Targets / Anmol Chandele, Amit Sharma -- Mathematical Approaches to Drug and Target Discovery. Mathematical Modeling and Omic Data Integration to Understand Dynamic Adaptation of Apicomplexan Parasites and Identify Pharmaceutical Targets / Partho Sen, Henri J Vial, Ovidiu Radulescu -- Understanding Protozoan Parasite Metabolism and Identifying Drug Targets through Constraint-Based Modeling / Francis Isidore Totanes, Sanu Shameer, David R Westhead, Fabien Jourdan, Glenn A McConkey -- Attacking Blood-Borne Parasites with Mathematics / David D Niekerk, Gerald Penkler, Francois Toit, Jacky L Snoep, Barbara M Bakker, Jurgen R Haanstra