Thymic development and selection of T Lymphocytes /
نام عام مواد
[Book]
نام نخستين پديدآور
Thomas Boehm, Yousuke Takahama, editors
مشخصات ظاهری
نام خاص و کميت اثر
1 online resource (vii, 132 pages) :
ساير جزييات
illustrations (some color)
فروست
عنوان فروست
Current Topics in Microbiology and Immunology,
مشخصه جلد
volume 373
شاپا ي ISSN فروست
0070-217X ;
يادداشت کلی
متن يادداشت
Includes index
یادداشتهای مربوط به کتابنامه ، واژه نامه و نمایه های داخل اثر
متن يادداشت
Includes bibliographical references and index
یادداشتهای مربوط به مندرجات
متن يادداشت
Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function -- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes
بدون عنوان
0
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity