cAMP specific phosphodiesterases : modulation, inhibition and activation / R.T. Cameron and G.S.Baillie -- Protease activated receptor-2 / Qihai Gu and Lu-Yuan Lee -- Voltage gated sodium channels as therapeutic targets / Richard J. Lewis -- Multi-target drugs for stabilisation of calcium cycling and neuroprotection in neurodegenerative diseases and stroke / M.G Antonio ... [et al.] -- Oligomerisation of g-protein coupled receptors / Juan F. L�opez-Gimnez and Javier Gonz�alez-Maeso -- Sigma-1 receptor chaperone : pharmacology and therapeutic perspectives / Daniel Zamanillo ... [et al.] -- Lipid as new targets / Eduardo Dom�inguez -- Knowledge base for nuclear receptor drug discovery / Albert A. Antol�in and Jordi Mestres -- Gene promoters and transcription control regions as therapeutic targets / Antonio Zorzano ... [et al.] -- Roles of glucagon-like peptide and glucose-dependent insolinotropic polypeptide hormones in brain function and neurodegeneration / Christian Holscher -- The exocytotic machinery as a target for the development of new drugs for schizophrenia / Mar�ia Jose Guerrero ... [et al.] -- Targeting epigenetic abnormalities in the brain / Erin Y. Sterner, Lisa E. Kalynchuk, and Hector J. Caruncho -- Rodent models as tools to discover novel therapeutic targets in the brain : the case of epilepsy / Justin J. Botterill ... [et al.] -- New approaches applied to drug screening / J. Brea, M.I. Loza.