تحليل بقاي بيماران تاالسمي ماژور با مدل وایبول و گمپرتز
General Material Designation
[طرحهای تحقیقاتی و پروژهها]
First Statement of Responsibility
اکبر بیگلریان
Subsequent Statement of Responsibility
رضا علی اکبرخویی
.PUBLICATION, DISTRIBUTION, ETC
Place of Manufacture
علوم توان بخشی و سلامت اجتماعیUniversity of Social Walfare and Rehabilitation
Date of Manufacture
۱۳۹۶
GENERAL NOTES
Text of Note
پیوست
SUMMARY OR ABSTRACT
Text of Note
Background: Thalassemia major (TM) is a severe disease and the most common anemia in the world. The survival time of the disease and its risk factors is important for physicians. The purpose of this study is to apply the proportional hazards (PH) and accelerated failure time (AFT) model in identifying the risk factors relating to survival of TM patients.Methods: The data of this historical cohort study, 296 patients with TM, was gathered during 1994- 2013 in Zafar Clinic in Tehran. Gompertz PH and Weibull AFT model were used to survival analysis (SA) of these patients. Data analysis was carried out with R3.2.2 software.Results: 51.7% of patients were women. Mean (± SD) of patients’ age was 29.11 (±0.47)year. One-year survival rate for men and women were 0.963±0.007 and 0.973±0.013 respectively; and also three-year survival rate for men and women were 0.711±0.057 and 0.733±0.114 respectively. In the Gompertz and Weibull models, birth place, and age at onset disease factors were significant (p=0.035 and p=0.005, and also p=0.013 and p=0.008, respectively) with survival time. The Akaike Information Criterion (AIC) for Weibull model was 158.51.Conclusion: According to the results, the Weibull AFT model is considered as the better model for identifying the risk factors relating to survival of TM disease.Keywords: Survival analysis, accelerated failure time model, proportional hazards models, thalassemia major
PARALLEL TITLE PROPER
Parallel Title
Survival analysing of the thalassemia major patients using Weibull and Gompertz models