عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Country Code
IR
Number
۶۰۹پ
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
فارسی
COUNTRY OF PUBLICATION OR PRODUCTlON
Country of publication
IR
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
کاربرد رگرسیون منطقی در تعیین اثرات متقابل پلی مورفیسم های ژنتیکی موثر در ابتلا به آلزایمر دیررس
General Material Designation
[پایان‌نامه]
Parallel Title Proper
Application of Logic Regression in Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer Morbidity
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
علوم بهزیستی وتوانبخشی university of social welfare and rehabilitation))
Date of Publication, Distribution, etc.
، ۱۳۹۰
PHYSICAL DESCRIPTION
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۱۰۰ص.
NOTES PERTAINING TO PUBLICATION, DISTRIBUTION, ETC.
Text of Note
چاپی
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
کارشناسی ارشد
Discipline of degree
آمارزیستی Biostatistics
Date of degree
۱۳۹۱/۰۲/۲۵
Body granting the degree
علوم بهزیستی وتوانبخشی university of social welfare and rehabilitation))
SUMMARY OR ABSTRACT
Text of Note
and VDR genes, and then the feature selection approach was used to detect the interactions between these polymorphisms and measure the significance of each one of them. In order to find significant logic combinations throughout the search environment, simulated annealing search algorithm was used. For the analysis of the data, the R Software, version 2.13.2, was used.Of all the individual effects and interactions specified by the feature selection approach, the individual effect of polymorphism in SAITOHIN, the twoway interaction between the polymorphisms of SAITOHIN and APOE genes, and three-way interaction among the polymorphisms of SAITOHIN and APOE and VDR genes was found significantly influential in occurrence of sporadic Alzheimer.Feature selection approach is recommended for the detection of interactions in genetic association studies with many variables.Keywords: Logic regression, Feature selection, Interactions, Genetic Polymorphisms, Sporadic Alzheimer ع-Genetic polymorphisms interactions are among the important factors in affliction with complex diseases like Alzheimer. In genetic association studies identify a combination of polymorphisms and measure their significance in increasing the risk of occurrence of such diseases is considered. The aims of present study is to use the feature selection approach in order to identify genetic polymorphisms interactions influential in affliction with Alzheimer.Totally, 101 sporadic Alzheimer cases and 109 control subjects, all above 65 years of age, from Iranian population were participating in a cross-sectional study.The evaluation of genes in the two groups was carried out using molecule identification methods; in particular, the PCR-RFLP technique was used to evaluate the intended polymorphisms in APOE, ABCA1, CALHM1, CCR2, GSK3B,SAITOHIN, TAU, TNF
ba
PARALLEL TITLE PROPER
Parallel Title
Application of Logic Regression in Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer Morbidity
TOPICAL NAME USED AS SUBJECT
Logic regression
(SUBJECT CATEGORY (Provisional
Subject Category Entry Element Text
رگرسیون منطقی
Subject Category Entry Element Text
Logic regression
PERSONAL NAME - PRIMARY RESPONSIBILITY
ترکش اصفهانی، نجیمه
Tarkesh Esfahani, Najimeh
PERSONAL NAME - SECONDARY RESPONSIBILITY
بیگلریان، اکبر
رهگذر، مهدی
ORIGINATING SOURCE
Country
ایران
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دانشگاه علوم توان بخشی و سلامت اجتماعی
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609..PDF
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محرمانه
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محرمانه
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6091.PDF
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6453352
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متن
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0
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۹۰۶پایا
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محل نگهداری: دانشگاه علوم بهزیستی و توانبخشی
نمایه‌سازی قبلی
چاپی-الکترونیکی
TF
1
a
Y
