عنوان

سنتز نانوهیدروژل‌های حساس حرارتی بر پایه پلیمرهای زیست تخریب‌پذیر

Number

‭۱۲۲۶۴پ‬

.Language of Text, Soundtrack etc

per

Title Proper

سنتز نانوهیدروژل‌های حساس حرارتی بر پایه پلیمرهای زیست تخریب‌پذیر

First Statement of Responsibility

/مرضیه فتحی

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: دانشکده شیمی

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‮‭۲۲۳‬ص‬

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چاپی

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فاقد چکیده فارسی

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دکتری

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در رشته شیمی آلی گرایش پلیمر

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‮‭۱۳۹۲/۱۱/۲۵‬

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تبریز

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‮‭loaded magnetic nanohydrogel-responsive behaviors of the synthesized magnetic nanohydrogels are investigated and finally, the cytotoxicity and drug loading are examined with mitoxantrone (MTX) as an anticancer drug model. The results confirm the low toxicity and enhanced anticancer effect of MTX- and temperature-IR, XRD, DSC, TGA and VSM. Also, pH-MNPs) nanohydrogels are characterized by TEM, DLS, FT-(starch-g-IA)-co-MNPs) and (PNIPAAm-(starch-g-responsive magnetic nanohydrogels. The obtained PNIPAAm- and pH-MNPs to prepare the thermo-maleate-responsive nanohydrogels, NIPAAm and itaconic acid (IA) are successfully polymerized from the vinyl double bonds of the starch-IR, XRD, TEM, UVvis and magnetic properties have been studied with vibrating sample magnetometer. Finally, for the preparation of ternary stimuli-modified PEG, PVA and starch shell via forming an inclusion complex between carboxylic acid groups of maleated biocompatible polymers and Fe۳O۴ MNP core surface. For this purpose, the carboxylated PEG, PVA and starch, which are synthesized by esterification with maleic anhydride (MA), are chemically absorbed on the surface of Fe۳O۴ MNPs. The properties of the synthesized coreshell nanaoparticles are characterized by FT-transition temperatures of the nanohydrogels obtained are then analyzed. Their swelling properties, such as the variations in their equilibrium swelling ratios with temperature and pH, their deswelling kinetics, and oscillatory swelling are also studied. In the next part, new route to prepare highly stable Fe۳O۴ MNPs aqueous dispersion using maleate-NIPAAm nanohydrogels are synthesized with different NIPAAm/PVA feed ratios and H۲O۲ concentrations. The structures, compositions, thermal stabilities, rheological behaviors, cytotoxicities, and phase-g-radical polymerization at the boiling point of water in very dilute solution, using H۲O۲ as an initiator. PVA-NIPAAm nanohydrgels are performed with different feed composition ratio of PVA, H۲O۲ and radiation dose to investigate the structure, the swelling behavior, size distribution, LCST, thermal and rheological properties of synthesized nanohydrogels. To evaluate the structure of the obtained nanohydrogels, the theory of Flory is used for the case of a swollen network to calculate the number average molecular weight between crosslinks (Mc) and crosslinking density (x). In the second part, a novel method for the preparation of nanohydrogels of NIPAAm based on the intramolecular collapse method under diluted conditions is developed. In this approach, NIPAAm is grafted onto biocompatible linear PVA chains via free-g-NIPAAm nanohydrogels. To perform the polymerization with much less radiation dose (۱۲۰ Gy) that provides a facile and simple equipment method for the synthesis of nanohydrogels in comparison with methods applying high radiation dose or crosslinking agents, the THPC as rapid oxygen scavenger and H۲O۲ as a source of hydroxyl radicals are used. Synthesis of PVA-g-biodegradability of the produced substances and must be completely removed from the final product. In this work, convenient and simple preparation methods are proposed for the synthesis of NIPAAm nanohydrogels without the use of toxic crosslinker agents based on biocompatible and biodegradable polymers. Therefore in the first section, a convenient radiation preparation method is proposed for the synthesis of PVA-interpenetrating polymer network to improve the response rate of the hydrogels. Additionally, to prepare PNIPAAm nanohydrogels, toxic materials such as crosslinking agents and surfactants are often employed, which greatly limited their clinical applications due to non-C. However, PNIPAAm hydrogels exhibited some limitations including slow response rate and low mechanical strength and biocompatibility. Several efforts have been proposed to adjust the hydrogel network structure by copolymerizing with hydrophilic monomers and introducing semisensitive hydrogels which undergoes a reversible phase transition temperature around the lower critical solution temperature (LCST) which is about ۳۲ -isopropylacrylamide) (PNIPAAm) hydrogel is one of the most extensively studied thermo-responsive nanosystem capable of response to an internal or external trigger such as pH, temperature, enzymes, magnetic, or ultrasound. Furthermore, incorporation of magnetic nanoparticles into stimuli responsive polymers offers additional advantages and multi functionality in the field of nanomedicine. poly(N-Due to large surface area, nanohydrogels present interesting properties. The new devices would lead to a reduction in the minimum effective dose of the drug required for each target. Smart polymers have attracted significant attention in the biomedical field wherein stimuli‬

فتحی، مرضیه

علی‌اکبر انتظامی

ارسلانی، ناصر، استاد راهنما

فرج اللهی، علیرضا، استاد مشاور

استاد مشاور

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