عنوان

سنتز نانودندریمرهای کربوسیلوکسانی جدید، بررسی خواص و کاربرد آنها

Number

‭۱۸۷۵پ‬

.Language of Text, Soundtrack etc

per

Title Proper

سنتز نانودندریمرهای کربوسیلوکسانی جدید، بررسی خواص و کاربرد آنها

First Statement of Responsibility

/سعید جعفری راد

Name of Publisher, Distributor, etc.

تبریز : دانشگاه تبریز ، دانشکده شیمی ، گروه شیمی

Specific Material Designation and Extent of Item

‮‭۱۷۰‬ ص ، مصور جدول نمودار‭۳۰‬*‭۲۹‬ س.م + یک لوح فشرده‬

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چاپی

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واژه نامه بصورت زیرنویس

Dissertation or thesis details and type of degree

دکترا

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شیمی آلی

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‮‭۱۳۸۹/۱۰/۱۱‬

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تبریز : دانشگاه تبریز ، دانشکده شیمی ، گروه شیمی

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فناوری نانو دندریمر نانوحامل هیبرید اتصال کربوسیلوکسانی

Text of Note

.th aim of this research is promotion of our knowledge in preparation of the carbosiloxan-based dendritic hybrid macromolecules and their applications in nanotechnology area. Dendritic-polymer hybrids are generated as the new generations of the dendritic supramolecular using divergent method. This dendritic-polymer hybrids contain several copolymers of AB and ABA types with different functional groups. In the first part of this work we report a dendrimer with an open structure, which was obtained using trichlorosilane merely for synthesizing the first generation and methyldichlorosilane for the second and third generations, which is expected to be further development in generations easily through the divergent method. In this direction, several reaction conditions were tested such as temperature, Catalyst/C=C ratio, times of hydrosililation and alcoholysis reactions in order to maximize -CH=CH2 conversion yields.In order to study the transport and release characteristics of the linear-dendritic triblock copolymers, we applied conjugation of benzyl alcohol and encapsulation for the hydrophobic dye molecule, 1-(2-Pyridylazo)-2-naphtol, and then investigation on its release properties. Release rate of guest molecules from the copolymers depends on several factors such as type of interactions between host and guest molecules (chemical binding or kind of physical interactions), generation of linear-dendritic hybrids and pH.in the third step of this research work, we reply to the question that whether the synthezied carriers could encapsulate and release the real drugs in the Lab conditions (invitro). Regarding to the obtained critical micelle concentration (CMC) values, it appears that based on the acquired data for CMCs -are lower than those reported for other polymeric micelles and comparable with dendritic micelles- they must play such a role. The comparison was done in this thesis implies a very strong tendency of carbosiloxane triblock dendritic copolymers toward micelle formation and their relatively thermodynamically stable entitites. These dendritic supramolecules also were used as the nanocarrier agents in whom some of hydrophobic drug molecules, naltrexone and erlotinib, and their hydrochloride salts were used as hydrophilic drugs respectively. The latest part directed toward designing a special kind of micellar aggregate based on amphiphilic linear-dendritic diblock copolymer. Its structure consists of hydrophilic polyethylene oxide monomethyl ether (PEOM) as hydrophilic block and carbosiloxane denditic branches as hydrophobic block. The dendritic block could be grafted by Magneson II, 4-(4-nitrophenylazo) 1-naphthol, as azo-chromophore which increases hydrophobicity for an amphiphilic character. The synthesized carriers were formed by self-aggregation in aqueous media. The azo-groups built compact packing in the core network of aggregates due to a strong non-covalent aromatic-aromatic interaction. Under the irradiation of UV light, the trans azo-groups with a rod-like shape are converted to the their cis ones with bent shape, which could disrupt the original relatively tight packing and bring a loose stacking formation in the aggregates. So by using this special property we could modify the incorporation contents of hydrophobic and hydrophilic drugs

Variant Title

1

جعفری راد، سعید

نمازی،حسن، استادراهنما

دیندارصفا، کاظم، استادمشاور

امیدی، یدالله، استادمشاور

000

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