عنوان

تاثیر مصرف حاد مقادیر مختلف سیر بر پاسخ عوامل انعقادی خون به یک جلسه فعالیت استقامتی شدید در مردان جوان ورزشکار,‮‭Effects of different doses of garlic supplementation on coagulation responses to a single bout of maximal exercise in young athletes‬

Text of Note

The aim of this study was to investigate the effects of different doses of garlic supplementation on coagulation responses to a single bout of maximal exercise in young athletes. Fifteen healthy young men (mean SD; age 27.0 7.9 years; weight 73.9 6.4 kg and height 175.3 4.3 cm) with at least 3 years experience of regular exercise in the endurance running and martial arts voluntarily participated in this study. Subjects took different doses of garlic (500,750 and 1000 mg) and starch (placebo) in four separate sessions. In each session, 4 hours after taking the supplement or placebo, subjects performed 30 min of running on treadmill at the intensity of 65-85 of target heart rate. Three blood samples were taken before supplementation, before exercise and immediately after exercise and were analyzed for fibrinogen (fib), factor VIII (FVIII), prothrombin time (PT) and partial thromboplastin time (aPTT). Repeated measure analysis and Bonferroni post-hoc test were used to analyze the data. Statistical significance was set at P < 0.05. Data analysis revealed that dosage of garlic had significant effect on fibrinogen, FVIII and aPTT in basic state (P0.05). Therefore, the most effective dose in reducing fibrinogen, FVIII and increasing aPTT was 500 mg of garlic. Garlic supplementation hindered the increase of fibrinogen and FVIII (P<0.05) and decrease of aPTT in response to exercise but there were no significant differences between doses (P0.05). Based on the findings of the present study, although garlic supplementation hindered the increase in coagulative factors induced by exercise, there were no significant differences between doses