INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
9781627030595
NATIONAL BIBLIOGRAPHY NUMBER
Country Code
IR
Number
EN-59759
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
COUNTRY OF PUBLICATION OR PRODUCTlON
Country of publication
IR
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Computational Toxicolog
General Material Designation
[Book]
Other Title Information
:Volume II
First Statement of Responsibility
/ edited by Brad Reisfeld, Arthur N. Mayeno
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Totowa, NJ
Name of Publisher, Distributor, etc.
: Humana Press :Imprint: Humana Press,
Date of Publication, Distribution, etc.
, 2013.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
XI, 648 p. 153 illus., 62 illus. in color., digital.
SERIES
Series Title
(Methods in Molecular Biology, Methods and Protocols,1064-3745
Volume Designation
; 930)
NOTES PERTAINING TO PUBLICATION, DISTRIBUTION, ETC.
Text of Note
Electronic
CONTENTS NOTE
Text of Note
Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing science, from streamlining drug efficacy and safety testing, to increasing the efficiency and effectiveness of risk assessment for environmental chemicals. Computational Toxicology provides biomedical and quantitative scientists with essential background, context, examples, useful tips, and an overview of current developments in the field. Divided into four sections, Volume I covers a wide array of methodologies and topics. Opening with an introduction to the field of computational toxicology and its current and potential applications, the volume continues with a??best practicesa?? in mathematical and computational modeling, followed by chemoinformatics and the use of computational techniques and databases to predict chemical properties and toxicity, as well as?aan overview of molecular dynamics.?a The final section is a compilation of the key elements and main approaches used in pharmacokinetic and pharmacodynamic modeling, including the modeling of absorption, compartment and non-compartmental modeling, physiologically based pharmacokinetic modeling, interspecies extrapolation, and population effects. Written in the successful Methods in Molecular Biologya?o series format where possible, chapters include introductions to their respective topics, lists of the materials and software tools used, methods, and notes on troubleshooting.Authoritative and easily accessible, Computational Toxicology will allow motivated readers to participate in this exciting field and undertake a diversity of realistic problems of interest.
Text of Note
Methods for Building QSARs -- Accessing and Using Chemical Databases -- From QSAR to QSIIR: Searching for Enhanced Computational Toxicology Models -- Mutagenicity, Carcinogenicity and Other Endpoints -- Classification Models for Safe Drug Molecules -- QSAR and Metabolic Assessment Tools in the Assessment of Genotoxicity -- Gene Expression Networks -- Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNetOptimizer -- Regulatory Networks -- Computational Reconstruction of Metabolic Networks from KEGG -- Biomarkers -- Biomarkers: Environmental Public Health Indicators -- Modeling for Regulatory Purposes (Risk and Safety Assessment) -- Developmental Toxicity Prediction -- Predictive Computational Toxicology to Support Drug Safety Assessment -- Developing a Practical Toxicogenomics Data Analysis System Utilizing Open-Source Software -- Systems Toxicology from Genes to Organs -- Agent Based Models of Cellular Systems -- Linear Algebra -- Ordinary Differential Equations -- On the Development and Validation of QSAR Models -- Principal Components Analysis -- Partial Least Square Methods: Partial Least Squares Correlation and Partial Least Square Regression -- Maximum Likelihood -- Bayesian Inference.
SERIES
Title
Methods in Molecular Biology, Methods and Protocols,1064-3745
Volume Number
930
TOPICAL NAME USED AS SUBJECT
Medicine
Toxicology
Biology, Data processing
Electronic books
LIBRARY OF CONGRESS CLASSIFICATION
Class number
E-BOOK
PERSONAL NAME - PRIMARY RESPONSIBILITY
Reisfeld, Brad.
PERSONAL NAME - SECONDARY RESPONSIBILITY
Mayeno, Arthur N
SpringerLink (Online service)
ORIGINATING SOURCE
Country
ایران
ELECTRONIC LOCATION AND ACCESS
Host name
9781627030588.pdf
Access number
عادی
Compression information
عادی
Date and Hour of Consultation and Access
9781627030588.pdf
Electronic Format Type
متن
old catalog
e
BL
1
a
Y
