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INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
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Includes bibliographical references and index.
CONTENTS NOTE
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Machine generated contents note: CONTENTS -- Preface vii --1.Cell Encapsulation: Generalities, Methods, Applications and Bioartificial Pancreas Case Study1 -- Gabriela Grigorescu and David Hunkeler -- Introduction 1 -- Immunoisolation 4 -- Cell Delivery 5 -- Microencapsulation 7 -- Bioartificial Organs 7 -- Case Study: Insulin Production Systems 10 -- Socio-Political Considerations 13 -- Conclusions 14 --2.Synthetic and Semisynthetic Polymers as Vehicles -- for In Vitro Gene Delivery into Cultured Mammalian Cells 19 -- Martin Jordan -- Introduction: Impact of Molecular Biology 19 -- Areas in Need of Efficient Gene Delivery 20 -- The DNA Molecule 21 -- Barriers to Efficient Gene Transfer 21 -- Conclusions 35 -- Definitions 36 -- Structures of Frequently Used Molecules 37 --3.Affinity Precipitation: Stimulus-Responsive Polymers for Bioseparation 40 -- Ruth Freitag -- Introduction 40 -- The Role of Affinity Separations in Product Isolation 41 -- The Principle and Application of Affinity Precipitation 43 -- Smart Polymers for Affinity Precipitation 48 -- Thermosensitive AML 50 -- Introduction of the Affinity Mediator 53 -- Conclusions and Outlook 54 --4.Synthetic Displacers for Preparative Biochromatography 58 -- Ruth Freitag and Christine Wandrey -- Introduction 58 -- The Principle of Displacement Chromatography 59 -- Displacers for Biochromatography 64 -- Polyelectrolytes 73 -- Steric Mass Action Model 77 -- Systematic Displacer Design, Some Theoretical Considerations 82 -- Conclusions 84 -- 5.Membrane Adsorbers for Decontamination and Leukocyte Removal 87 -- Galya Tishchenko and Miroslav Bleha -- Introduction 87 -- Evaluation of the Adsorbing Efficiency of Interactive Membranes 88 -- Membranes for Depyrogenation (Endotoxin Removal) 90 -- Membranes for Removal of Bacteria and Viruses -- from Aqueous Solution 108 -- Membranes for Removal of Leukocytes from Blood Products 110 -- Conclusions 112 --6.Stimulus Responsive Surfaces: Possible Implications -- for Biochromatography, Cell Detachment and Drug Delivery 116 -- Igor Yu Galaev and Bo Mattiasson -- Stimulus-Responsive Polymers 117 -- Polymer-Grafted Surfaces 119 -- Temperature-Responsive Chromatography 120 -- Cell Detachment from Polymer-Grafted Surfaces 122 -- Controlling Porosity via Smart PolymersThe "Chemical Valve" 125 -- Polymer-Carrying Liposomes for Triggered -- Release/Drug Delivery 127 -- Conclusions 129 --7.Molecularly Imprinted Polymers: A New Dimension in Analytical Bioseparation 134 -- Oliver Briiggemann -- Introduction 134 -- The Principle of Molecular Imprinting134 -- MIP for Bioseparation 141 -- Binding Assays Using MIP 149 -- Sensor Technology 151 -- MIP to Assist Chemical Synthesis 151 -- Conclusions 154 --Index 163.