عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TLpq2408869575
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Understanding the Interplay Between Viral and Host Dynamics
General Material Designation
[Thesis]
First Statement of Responsibility
Vera Cruz, Diana
Subsequent Statement of Responsibility
Koelle, Katharina
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
Duke University
Date of Publication, Distribution, etc.
2020
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
151
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Body granting the degree
Duke University
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
The evolution of antigenically variable viruses cannot be understood without studying the interaction between viruses and the host immune system. Viral evolution is driven by their fast acquisition of genetic variation as well as by the strong selection imposed by the host immune response. Moreover, understanding viral evolution dynamics and its interplay on the host immune response can provide essential information for vaccine development. In this dissertation, I use an integrative approach to study various aspects of this interplay in two viral systems: influenza A (IAV) and cytomegalovirus (CMV), both ubiquitous in humans and significant public health threats.
TOPICAL NAME USED AS SUBJECT
Antigenic imprinting
Biology
Cytomegalovirus
Influenza
Vaccination
Viral evolution
PERSONAL NAME - PRIMARY RESPONSIBILITY
Koelle, Katharina
Vera Cruz, Diana
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
