عنوان

Supplementation of Omega-3 Fatty Acid in Women During Pregnancy:

Number

TLpq2404679938

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Supplementation of Omega-3 Fatty Acid in Women During Pregnancy:

General Material Designation

[Thesis]

First Statement of Responsibility

Su, Jessica

Title Proper by Another Author

An Approach that Can Potentially Reduce the Risk of Developing Postpartum Depression

Subsequent Statement of Responsibility

Gordon-Elliott, Janna

Name of Publisher, Distributor, etc.

Weill Medical College of Cornell University

Date of Publication, Distribution, etc.

2020

Specific Material Designation and Extent of Item

47

Dissertation or thesis details and type of degree

M.S.

Body granting the degree

Weill Medical College of Cornell University

Text preceding or following the note

2020

Text of Note

Problem: Postpartum depression (PPD) is one of the most common complications of childbirth and is a concerning major public health issue. PPD is associated with numerous adverse outcomes of the women and also the offspring and the family. If left untreated, PPD can affect the mental health of the women and also the development of the offspring. Purpose: The goal of this study is to investigate if supplementing omega-3 fatty acid to pregnant women during pregnancy can reduce the risk of developing PPD. Research Questions: Does supplementation of omega-3 fatty acid to women during pregnancy help reduce the risk of developing PPD? Methods: A randomized, double-blinded, placebo controlled clinical trial is proposed. Women who are between the ages of 18-45, in less than 12 weeks of gestation of a singleton pregnancy, with no other births in the previous two years, no chronic diseases or other psychiatric history, no current or history of major depressive disorder (MDD) and PPD, no family history of PPD, and no current substance abuse will be eligible for this study. Women who are taking antidepressants and/ or omega-3 fatty acid supplements, receiving psychotherapy, and who have a PHQ-9 score of five and above at baseline during screening will be excluded from the study. Research subjects will be recruited from Women, Infant, and Children (WIC) offices in the New York metropolitan area that are affiliated with New York Presbyterian Hospitals. Participants will be randomly assigned to 2 groups that will receive: 1) omega-3 FAs supplements containing a total of 830 mg omega-3 FAs that includes DHA/EPA (480 mg/205 mg) or 2) placebo (corn oil) from 14 weeks of gestation until 24 weeks after childbirth. Serum n-3 levels will be sampled and analyzed every 12 weeks. Symptoms of depression will be assessed prior to delivery and every 4 weeks after childbirth until 12 months by using a self-report scale- the Patient Health Questionnaire-Nine Item (PHQ-9). Outcomes: Participants will be followed for depression symptoms and possible diagnosis of PPD until 12 months after childbirth Benefit: Supplementation of omega-3 fatty acid to women during early pregnancy and early postpartum period may reduce the risk of developing PPD.

Medicine

Nutrition

Omega-3 fatty acid

Postpartum depression

Pregnancy

Gordon-Elliott, Janna

Su, Jessica

Electronic name

p

[Thesis]

276903

a

Y