عنوان

Longitudinal Changes in Amygdala, Hippocampus and Cortisol Development Following Early Caregiving Adversity

Number

TLpq2388040240

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Longitudinal Changes in Amygdala, Hippocampus and Cortisol Development Following Early Caregiving Adversity

General Material Designation

[Thesis]

First Statement of Responsibility

VanTieghem, Michelle

Subsequent Statement of Responsibility

Tottenham, Nim L

Name of Publisher, Distributor, etc.

Columbia University

Date of Publication, Distribution, etc.

2020

Specific Material Designation and Extent of Item

99

Dissertation or thesis details and type of degree

Ph.D.

Body granting the degree

Columbia University

Text preceding or following the note

2020

Text of Note

Decades of research have shown long-term effects of early caregiving adversity on stress physiology and limbic brain regions, two key biological systems that are implicated in risk for internalizing disorders. Although stress physiology and limbic brain structure undergo significant maturational change during childhood and adolescence, and reciprocally influence each other, the effects of early caregiving adversity on these developmental processes is not well understood. In the current study, we used an accelerated longitudinal design to assess the development of stress physiology, amygdala, and hippocampal volume following early institutional care. Previously Institutionalized (PI; N = 93) and comparison (COMP; N = 161) youth (ages 4-20 years old) completed 1-3 waves of data collection, each spaced approximately 2 years apart, for diurnal cortisol (N = 239, providing a total of 380 diurnal datasets), structural MRI (N = 156, providing a total of 306 scans) and parent-reported internalizing symptoms (N = 133, providing a total of 227 time points). We observed a developmental shift in morning cortisol in the PI group, with blunted levels in childhood and heightened levels in late adolescence. PI history was associated with reduced hippocampal volume and reduced growth of the amygdala, resulting in smaller volumes by adolescence. Results also suggested feed-forward brain-to-hormone mechanisms, such that both amygdala and hippocampal volumes were prospectively associated with morning cortisol levels two years later. Finally, amygdala and hippocampal volumes were independently associated with internalizing scores across the entire sample. These results indicate that adversity-related physiological and neural phenotypes are not stationary during development but instead exhibit dynamic and interdependent changes from early childhood to early adulthood.

Amygdala

Cortisol

Early adversity

Hippocampus

HPA-axis

Psychology

Tottenham, Nim L

VanTieghem, Michelle

Electronic name

p

[Thesis]

276903

a

Y