عنوان

Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery

Number

TLpq2386952348

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery

General Material Designation

[Thesis]

First Statement of Responsibility

Jafari, Amin

Subsequent Statement of Responsibility

Cheng, Chong

Name of Publisher, Distributor, etc.

State University of New York at Buffalo

Date of Publication, Distribution, etc.

2019

Specific Material Designation and Extent of Item

184

Dissertation or thesis details and type of degree

Ph.D.

Body granting the degree

State University of New York at Buffalo

Text preceding or following the note

2019

Text of Note

Effective delivery of therapeutic agents, such as free drug molecules and genes, to specific biological sites presents a significant challenge for biomedical researchers. Several biological barriers are hindering the delivery of free therapeutic materials directly to the diseased tissue, such as degradation by serum protein absorption, macrophage internalization, sequestration in the reticuloendothelial system, clearance by the kidney, etc. Over the past decades, nanocarriers have emerged as promising biomaterials that may overcome biological barriers, protect the therapeutic cargo, and effectively deliver them to the diseased tissue. Polymer-based nanocarriers have drawn tremendous interest because of their significant potential to improve therapeutic biocompatibility, solubility, bioavailability, controlled release, and also minimizing therapeutic toxicity, and nonspecific interactions. With a thoughtful structural design, they can exhibit provide biomedical-relevant stimuli-responsive behavior via variables such as pH, light, and temperatures. The formulation of novel polymer-based nanocarriers for therapeutic delivery has been the focus of many researchers over the past decades. Aligned with such a research direction, this dissertation research includes two major projects: 1) nanocapsules preparation by layer-by-layer (LBL) self-assembly, and 2) synthesis and development of multiple polycaprolactone (PCL)-based nanocarriers for drug and gene delivery applications.

Biodegradable polymer

Drug and gene delivery

Functional biomaterial

Nanocapsule

Nanoparticle

Polymer chemistry

Cheng, Chong

Jafari, Amin

Electronic name

p

[Thesis]

276903

a

Y