The Impact of Strength and Range of Motion on Loss of Ambulation and Functional Change Measures in Boys with DMD
General Material Designation
[Thesis]
First Statement of Responsibility
Duong, Tina
Subsequent Statement of Responsibility
Canbek, Jennifer
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
Nova Southeastern University
Date of Publication, Distribution, etc.
2020
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
174
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
P.T.P.
Body granting the degree
Nova Southeastern University
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
Duchenne muscular dystrophy (DMD) is an x-linked lethal progressive disorder affecting boys who are typically diagnosed due to motor delays or weakness. Key features include loss of motor function throughout the lifetime resulting in early mortality from cardiopulmonary complications in the late 2nd and 3rd decades of life. Rates of progression are variable yet sequential due to a typical pattern of motor weakness that occurs from proximal to distal muscle groups. Current standards of care include contracture management and Glucocorticosteroids (GC). Timed function tests have been used to understand and predict loss of functional milestones such as walking, getting off the ground and going upstairs. This study will describe contracture development; associated strength loss and its effect on function for boys with DMD. With differing rates of decline in boys with DMD, this study will also determine minimal clinical important difference (MCID) based on annual progression rates of 3 critical timed function tests (supine to stand, climb 4 stairs and 10meter walk test).