عنوان

Voltammetric assays and behavior of norfloxacin and nalidixic acid antibacterial drugs

Number

TLpq230940034

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Voltammetric assays and behavior of norfloxacin and nalidixic acid antibacterial drugs

General Material Designation

[Thesis]

First Statement of Responsibility

A. Lounici

Name of Publisher, Distributor, etc.

King Fahd University of Petroleum and Minerals (Saudi Arabia)

Date of Publication, Distribution, etc.

1993

Specific Material Designation and Extent of Item

216

Dissertation or thesis details and type of degree

M.S.

Body granting the degree

King Fahd University of Petroleum and Minerals (Saudi Arabia)

Text preceding or following the note

1993

Text of Note

This thesis describes the work done on the voltammetric assays, physicochemical behavior, and mechanistic studies of norfloxacin and nalidixic and antibacterial drugs at the dropping mercury electrode (DME) and at the hanging mercury drop electrode (HMDE). Easy, precise, accurate and fast analytical procedures have been developed for the quantitative determination of norfloxacin and nalidixic acid in formulated tablets using differential pulse polarography (DPP), linear scan voltammetry (LSV) and adsorptive striping voltammetry (AdSV). Good working ranges and recoveries with small standard deviations were obtained in the determination of both antibacterials using DPP and LSV techniques with a detection limit of 1 ppm (1 mg/l). Determination of ultra-trace of norfloxacin was possible using the AdSV with a detection limit of 0.31 ppt (0.31 ng/l). The voltammetric behavior and mechanistic study of norfloxacin and nalidixic acid were investigated. Norfloxacin was found to be reduced in one electron step in strongly acidic and in alkaline solution. However, it is reduced in 2 one electron steps in slightly acidic to slightly alkaline solutions (pH 5.5-8.0). The two main reduction waves were found to be irreversible and diffusion controlled with scan rates >20 mV/sec. However, the other smaller waves showed different degree of reversibility depending on the scan rate and were found to be adsorption controlled. Nalidixic acid is found to be reduced in 2 one electron steps in strongly acidic medium and in slightly acidic to slightly alkaline solutions. However, it is reduced in one electron only in alkaline solutions. Its reduction processes were found to be completely irreversible and diffusion controlled.

Chemistry

Pure sciences

A. Lounici

Electronic name

p

[Thesis]

276903

a

Y