عنوان

Chemical analysis of some penicillin and cephalosporin drugs

Number

TLpq230755001

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Chemical analysis of some penicillin and cephalosporin drugs

General Material Designation

[Thesis]

First Statement of Responsibility

S. S. Yassin

Name of Publisher, Distributor, etc.

King Fahd University of Petroleum and Minerals (Saudi Arabia)

Date of Publication, Distribution, etc.

1991

Specific Material Designation and Extent of Item

179

Dissertation or thesis details and type of degree

M.S.

Body granting the degree

King Fahd University of Petroleum and Minerals (Saudi Arabia)

Text preceding or following the note

1991

Text of Note

This thesis describes work on the polarographic analysis of pencillin and cephalosporin antibiotics. Methods for the quantitative analysis of Ampicillin, Amoxycillin and Cephalexin were developed. These methods are based on the formation of Ni(II) or Co(II) complexes of the antibiotics or on degradation products namely, 2,5-diketopiperazine derivatives. The optimum conditions of buffering, support electrolyte, pH, temperature and the effect of time were studied for the Ni(II) complexes of Ampicillin and Amoxycillin. Under these optimum conditions, linear calibration ranges were usd5.00\times 10\sp{-7}usd to usd1.00\times 10\sp{-5}Musd and usd4.00\times 10\sp{-7}usd to usd2.00\times 10\sp{-5}Musd for Ampicillin and Amoxycillin respectively. Reversibility tests suggest that the electrode reactions are probably reversible and they are one electron transfer processes. The Co(II) complex of Cephalexin was compared with that of Ni(II) for the analysis and found to be inferior. A satisfactory method based on the formation of the 2,5-diketopiperazine derivatives of Amoxycillin was developed. The methods devised were tested on pharmaceutical products (capsules) and the results compared with pharmacopoeia methods. Good agreement was obtained.

Analytical chemistry

Analytical chemistry

Pharmacology

Pure sciences

S. S. Yassin

Electronic name

p

[Thesis]

276903

a

Y