عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TLpq303918510
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Virus and chemical-induced immunosuppression in nonhuman primates
General Material Designation
[Thesis]
First Statement of Responsibility
M. A. Javadian
Subsequent Statement of Responsibility
J. L. Botsford
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
New Mexico State University
Date of Publication, Distribution, etc.
1991
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
118
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Body granting the degree
New Mexico State University
Text preceding or following the note
1991
SUMMARY OR ABSTRACT
Text of Note
A successful cellular immune response includes macrophages, neutrophils, natural killer cells, and lymphocytes. Modulation or interference with any of these components leads to suppression of the host immune response. The effects of hepatitis B (HBV), hepatitis Non-A, Non-B (NANB) human immunodeficiency virus (HIV), and the chemical pesticide, heptachlor, on the initial aspects of immune response of exposed chimpanzees were investigated. The effects of HBV, NANB, and HIV on the function of polymorphonuclear leukocytes (PMN) were studied by employing a chemiluminescence (CL) assay. The present data have shown that all three viruses impair the generation of the respiratory burst by PMNs. The effect of viruses and heptachlor on the blastogenesis of chimpanzee lymphocytes was investigated by mitogenic stimulation and mixed lymphocyte reactions (MLR). Exposure of chimpanzee lymphocytes to heptachlor produced a significant decrease on the proliferative response of mitogens and mitomycin-treated allogenic cells. The natural killer (NK) cell cytotoxicity of HIV-infected chimpanzees was measured by Cr-release assay. The data from this study indicate that NK cytotoxic function was severely compromised in HIV-infected chimpanzees. Of potential relevance was the observation that cytolytic activity of depressed NK cells was restored after in vitro treatment with interleukin-2. Evidence from this study indicates that effects of heptachlor on the initial aspects of immune response in non-human primates are very much like that caused by HIV and hepatitis viruses.
TOPICAL NAME USED AS SUBJECT
Biological sciences
Health and environmental sciences
Immunology
Immunology
Microbiology
Toxicology
PERSONAL NAME - PRIMARY RESPONSIBILITY
J. L. Botsford
M. A. Javadian
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
