عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TLpq2436795930
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Searching for New Analgesics Without Addiction Risks
General Material Designation
[Thesis]
First Statement of Responsibility
Rahman, Mohammad Atiqur
Subsequent Statement of Responsibility
Keck, Thomas M.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
Rowan University
Date of Publication, Distribution, etc.
2020
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
97
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.S.
Body granting the degree
Rowan University
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
Opioids are widely used to treat acute and chronic pain. But opioid addiction to these compounds can cause social and life-threatening health problems, including the risk of overdose. In this thesis, I evaluated IBNtxA (3-iodobenzoyl naltrexamine), a novel μ opioid receptor (MOR) agonist structurally related to the classical MOR antagonist naltrexone, in drug discrimination studies in order to better understand its subjective effects and more thoroughly its abuse liability. IBNtxA represents an intriguing lead compound for preclinical drug development specifically targeting MOR splice variants, potentially creating effective analgesics with reduced side effects. These results indicate that IBNtxA produces potent antinociception and has low abuse liability, likely driven by substantial κ opioid receptor agonist signaling effects. I also evaluated whether a combination of drugs can produce synergistic antinociceptive effects. Using von Frey testing and hot plate procedures, I measured the antinociceptive effects of morphine, the novel α2/α3 subunit-containing GABAA receptor positive allosteric modulator MP-III-024, and their combination. Combinations of morphine and MP-III-024 produced supra-additive effects in both assays, indicating some level of synergy from these compounds. Results from these studies may lead to the development of new analgesic treatments with improved side-effect profiles, including reduced abuse liability.
TOPICAL NAME USED AS SUBJECT
Pharmaceutical sciences
PERSONAL NAME - PRIMARY RESPONSIBILITY
Keck, Thomas M.
Rahman, Mohammad Atiqur
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
