عنوان

Enhanced Optical Tomography in Diffuse Media Using Optical Gating of Early Photons

Number

TLpq2424877269

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Enhanced Optical Tomography in Diffuse Media Using Optical Gating of Early Photons

General Material Designation

[Thesis]

First Statement of Responsibility

Ghosh, Aishwarya

Subsequent Statement of Responsibility

Tichauer, Kenneth M.

Name of Publisher, Distributor, etc.

Illinois Institute of Technology

Date of Publication, Distribution, etc.

2020

Specific Material Designation and Extent of Item

58

Dissertation or thesis details and type of degree

M.S.

Body granting the degree

Illinois Institute of Technology

Text preceding or following the note

2020

Text of Note

Tissue biopsies, where a volume of tissue is removed from a patient, typically through needle extraction, provides critical information about the cellular and molecular aspects of an individual patient's health and/or disease. However, current pathological assessments of tissue biopsies evaluate less than 1% of the volume of the tissue (e.g., one to a few 5-micron slices are sectioned out of the biopsy and stained/processed for microscopic analysis). Since the bulk of tissue biopsy is carried out through optical imaging (absorption or fluorescence), a more 3D, "whole-biopsy" view is conceivably possible with optical projection tomography (OPT). The challenge with OPT has been that for clinically relevant sized biopsies, most photons undergo multiple scattering events that lead to loss of spatial resolution that makes accurate pathological analysis intractable. In my MS thesis, I worked on the development of an enhanced OPT system that employs optical gating based on non-linear up-conversion of infrared ultrashort laser pulses to isolate "early-arriving" photons that experience significantly less scatter than the bulk of photons transiting a scattering biological sample. Considering the complexity of such a system, the entirety of my MS thesis work was spent constructing and testing the femtosecond optical gated OPT system and though I was unable to validate its operation in biological samples, simulations suggest that the properties we were able to achieve could allow high resolution optical imaging in 0.1-1 cm-diameter specimens.

Bioengineering

Engineering

Optics

Ghosh, Aishwarya

Tichauer, Kenneth M.

Electronic name

p

[Thesis]

276903

a

Y