عنوان

Reducing Antibiotic Consumption in Patients with Asymptomatic Bacteriuria:

Number

TLpq2323168431

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Reducing Antibiotic Consumption in Patients with Asymptomatic Bacteriuria:

General Material Designation

[Thesis]

First Statement of Responsibility

Mozafarihashjin, Mohammad

Title Proper by Another Author

A Bi-directional Approach

Subsequent Statement of Responsibility

McGeer, Allison Joan

Name of Publisher, Distributor, etc.

University of Toronto (Canada)

Date of Publication, Distribution, etc.

2019

Specific Material Designation and Extent of Item

146

Dissertation or thesis details and type of degree

M.Sc.

Body granting the degree

University of Toronto (Canada)

Text preceding or following the note

2019

Text of Note

Objectives: To assess safety and effectiveness of not processing midstream urine (MSU) in adults to reduce asymptomatic bacteriuria (ASB) treatment, and find a biomarker that differentiates symptomatic urinary tract infection (SUTI) from ASB in adults. Methods: From 11/2013-04/2019 MSU for surgical/medical in-patients were routinely not processed. Patients were followed up for 4 and 30 days. Primary outcome was safety; secondary outcomes were antibiotic use, lab workload, and rate/proportion of MSU submitted/processed. A systematic review was conducted to identify potential biomarkers. Results: In 912 patients, no serious adverse events (AE) and 6 (0.66%) non-serious AE occurred due to not processing MSU. Processed MSU proportion, submitted MSU rate, and lab workload decreased (P=0.002; P=0.02; 5 person-days/year). Ninety-eight patients avoided antibiotics. Urine IL-6 and IL-8 were the most promising biomarkers. Conclusion: Not processing MSU reduces ASB treatment safely and effectively. Urine IL-6 and IL-8 could possibly differentiate ASB from SUTI.

Epidemiology

Health sciences

Medicine

McGeer, Allison Joan

Mozafarihashjin, Mohammad

Electronic name

p

[Thesis]

276903

a

Y