عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TLpq2202968104
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
The Role of Alcohol Dehydrogenase Evolution in Alcohol Adaptation of Drosophila Melanogaster
General Material Designation
[Thesis]
First Statement of Responsibility
Siddiq, Mohammad
Subsequent Statement of Responsibility
Thornton, Joseph W.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
The University of Chicago
Date of Publication, Distribution, etc.
2019
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
103
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Body granting the degree
The University of Chicago
Text preceding or following the note
2019
SUMMARY OR ABSTRACT
Text of Note
A central goal of evolutionary biology is to understand the genetic and functional mechanisms through which organisms become adapted to their environments. Testing specific hypotheses about effects of historical genetic changes on organismal functions and fitness, however, has been a major challenge in the field of evolutionary genetics since its inception. This dissertation begins with a brief review covering the history of and historical challenges in evolutionary studies of genetic adaptation. The subsequent chapters report findings from new experimental investigations, using recently developed methods in molecular biology and biochemistry, of two iconic hypotheses of molecular adaptation concerning evolution of the fruitfly alcohol dehydrogenase enzyme (ADH) between and within species. In both of these cases, the results show how historical evolution of ADH happened differently than predicted and highlight the importance of experimentally testing adaptive hypotheses. Further, this work establishes a method-reconstruction of ancestral genes and tests of their biochemical functions in vitro and physiological functions in vivo using transgenic organisms-that allows testing of previously untestable adaptive hypotheses. The last chapter reports emerging themes in protein evolution about the number and biochemical nature of genetic changes involved in the origin and differentiation of molecular specificity.
TOPICAL NAME USED AS SUBJECT
Biology
Evolution and Development
Genetics
PERSONAL NAME - PRIMARY RESPONSIBILITY
Siddiq, Mohammad
Thornton, Joseph W.
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
