عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL53695
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Ketamine Pre-Exposure Does Not Influence Later-Life Responses to Reward-Related Stimuli in Female C57BL/6 Mice
General Material Designation
[Thesis]
First Statement of Responsibility
Carachure, Israel Garcia
Subsequent Statement of Responsibility
Iñiguez, Sergio D.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
The University of Texas at El Paso
Date of Publication, Distribution, etc.
2020
GENERAL NOTES
Text of Note
46 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.A.
Body granting the degree
The University of Texas at El Paso
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
Preclinical work indicates that exposure to traditional antidepressant medications, in adolescent and adult female subjects, alters reward-related behavior later in life. In recent years, the anesthetic ketamine (KET), now used as a fast-acting antidepressant, has shown promising therapeutic efficacy for the management of depression. However, the potential long-term behavioral consequences of KET exposure across development have not been thoroughly assessed. Thus, to address this issue, we examined if KET exposure, during adolescence or early adulthood, results in enduring alterations in responsivity to the rewarding properties of sucrose and cocaine later in life. Specifically, female C57BL/6 mice were randomly assigned to receive repeated intraperitoneal injections of KET (0 [vehicle; VEH] or 20 mg/kg) for 15 consecutive days during the adolescent (postnatal day [PD] 35-49), or early adult (PD70-84) stage of development. Twenty-one days after KET or VEH exposure, female mice (PD70+ or PD105+, respectively) were assessed on their reactivity to a sucrose solution (1%) adopting a two-bottle choice procedure, or cocaine (0, 5, or 10 mg/kg) using the conditioned place preference test, two well-established measures of reward-seeking behavior. We found that 21-days post KET exposure, female mice spent significantly higher time in the cocaine-paired chamber (p<0.05). However, KET pre-exposure, either during adolescence (PD35-49) or early adulthood (PD70-84), did not influence the preference magnitude for sucrose or cocaine 21-days later (PD70+ and PD105+, respectively). Collectively, our data suggest that exposure to KET does not induce long-term changes to reward-related stimuli, in female C57BL/6 mice.
UNCONTROLLED SUBJECT TERMS
Subject Term
Developmental psychology
Subject Term
Experimental psychology
Subject Term
Mental health
Subject Term
Neurosciences
Subject Term
Pharmacology
Subject Term
Psychobiology
PERSONAL NAME - PRIMARY RESPONSIBILITY
Carachure, Israel Garcia
PERSONAL NAME - SECONDARY RESPONSIBILITY
Iñiguez, Sergio D.
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
The University of Texas at El Paso
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
