عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL53317
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Characterization and Evolution of Intracellular Survival in Bordetella
General Material Designation
[Thesis]
First Statement of Responsibility
Rivera, Israel
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of Georgia
Date of Publication, Distribution, etc.
2020
GENERAL NOTES
Text of Note
170 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Body granting the degree
University of Georgia
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
The classical bordetellae possess several partially characterized virulence mechanisms that are studied in the context of a complete extracellular life cycle in their mammalian host. Yet, classical bordetellae have repeatedly been reported within dendritic cells and alveolar macrophages in clinical samples, and in vitro experiments convincingly demonstrate that the bacteria can survive intracellularly within mammalian phagocytic cells, an ability that appears to have descended from ancestral progenitor species that lived in the environment and acquired the mechanisms to resist unicellular phagocytic predator. Many pathogens, including Mycobacterium tuberculosis, Salmonella enterica, Francisella tularensis, and Legionella pneumophila are known to parasitize and multiply inside eukaryotic host cells. This strategy provides protection, nutrients, and the ability to disseminate systemically. While some work has been dedicated at characterizing B. pertussis intracellular survival phenotype, there is very little understanding of how this strategy has evolved within the genus Bordetella and contributes to bacterial pathogenicity, evasion of host immunity and systemic dissemination. Here, we explore the mechanisms that control the changes accompanying intracellular survival and how these have been acquired and conserved throughout the divergent evolutionary histories of Bordetella species.
UNCONTROLLED SUBJECT TERMS
Subject Term
Bioinformatics
Subject Term
Microbiology
Subject Term
Molecular biology
PERSONAL NAME - PRIMARY RESPONSIBILITY
Rivera, Israel
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
University of Georgia
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
