عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL53252
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
A Study of Bacterial Translation at Codon Resolution Using Ribosome Profiling
General Material Designation
[Thesis]
First Statement of Responsibility
Mohammad, Fuad
Subsequent Statement of Responsibility
Nathans, Jeremy
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
The Johns Hopkins University
Date of Publication, Distribution, etc.
2020
GENERAL NOTES
Text of Note
178 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Body granting the degree
The Johns Hopkins University
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
Ribosome profiling has pushed the boundary of how translation is studied by illuminating every step of the translation cycle at the genome scale. First developed by Nick Ingolia and Jonathan Weismann, ribosome profiling is now widely used in both bacterial and eukaryotic studies. However, development of the method in bacteria has not achieved the level of refinement seen in yeast and mammalian ribosome profiling. This thesis focuses on analyzing the current methodology in bacteria to understand its strengths and shortcomings and developing improvements in both how libraries are prepared and how the data is analyzed. This thesis will also focus on implementing these improvements to understand events that influence translation elongation as well as how ribosome profiling can be used to identify new genes.
UNCONTROLLED SUBJECT TERMS
Subject Term
Bioinformatics
Subject Term
Molecular biology
PERSONAL NAME - PRIMARY RESPONSIBILITY
Mohammad, Fuad
PERSONAL NAME - SECONDARY RESPONSIBILITY
Nathans, Jeremy
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
The Johns Hopkins University
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
