عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL51779
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Bacteriophage Moron JBD30-4 Affects type IV Pilus and Flagellar Function in Pseudomonas aeruginosa
General Material Designation
[Thesis]
First Statement of Responsibility
Islam, Zafrin
Subsequent Statement of Responsibility
Maxwell, Karen
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of Toronto (Canada)
Date of Publication, Distribution, etc.
2019
GENERAL NOTES
Text of Note
69 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.Sc.
Body granting the degree
University of Toronto (Canada)
Text preceding or following the note
2019
SUMMARY OR ABSTRACT
Text of Note
Bacteriophages can influence the virulence of Pseudomonas aeruginosa, an opportunistic pathogen causing significant morbidity and mortality in immunocompromised individuals. Morons, specific prophage genes not required for the phage life cycle, provide fitness advantages to bacteria under specific environmental conditions. JBD30-4 is a phage moron that inhibits P. aeruginosa twitching and swimming motility while remaining susceptible to phage infection. An interaction detected using the bacterial adenylate cyclase two-hybrid system suggests that JBD30-4 mediates this phenotype through an interaction with the type IV pilus response regulator PilH. Biochemical characterization of JBD30-4 revealed that the N-terminus of the protein is critical for function. Downregulation of flagella and type IV pili upon expression of JBD30-4 from a prophage, leading to a decrease in motility, may enable bacterial evasion from the host immune system during P. aeruginosa infection, promoting survival of the bacteria and the prophage genome contained within it.
UNCONTROLLED SUBJECT TERMS
Subject Term
Biochemistry
Subject Term
Microbiology
Subject Term
Molecular biology
PERSONAL NAME - PRIMARY RESPONSIBILITY
Islam, Zafrin
PERSONAL NAME - SECONDARY RESPONSIBILITY
Maxwell, Karen
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
University of Toronto (Canada)
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
