عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL51639
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
A Preliminary Study of the Nociceptin Receptor System in Individuals with Psychosis
General Material Designation
[Thesis]
First Statement of Responsibility
Khan, Muhammad Saad
Subsequent Statement of Responsibility
Kolla, Nathan
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of Toronto (Canada)
Date of Publication, Distribution, etc.
2019
GENERAL NOTES
Text of Note
124 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.Sc.
Body granting the degree
University of Toronto (Canada)
Text preceding or following the note
2019
SUMMARY OR ABSTRACT
Text of Note
Psychosis is characterized by key positive symptoms and evidence potentially implicates the nociceptin receptor (NOPr) system in these processes. This pilot study investigates in vivo NOPr expression in individuals on the psychosis spectrum using the [11C]NOP-1A radioligand and positron emission tomography (PET). Evidence for dysregulation in dopamine, glutamate, and the hypothalamic-pituitary-adrenal axis is presented, followed by evidence of NOPr involvement in each of these systems. This pilot study aimed to assess feasibility, including recruitment, study procedures, and timeline, and also sample size estimation. Eight individuals with psychosis and eight healthy control individuals successfully completed study procedures. Results demonstrate that a total of 25 individuals would be needed in each group to detect a 20% difference between groups with 80% power and an alpha of 0.05, and the methodology employed in this internal pilot study would be appropriate to conduct a study with a larger sample size in the future.
UNCONTROLLED SUBJECT TERMS
Subject Term
Neurosciences
Subject Term
Psychobiology
PERSONAL NAME - PRIMARY RESPONSIBILITY
Khan, Muhammad Saad
PERSONAL NAME - SECONDARY RESPONSIBILITY
Kolla, Nathan
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
University of Toronto (Canada)
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
