Association of Obesity Phenotypes with Electrocardiographic Markers of Poor Outcomes in the General Population
General Material Designation
[Thesis]
First Statement of Responsibility
Ahmad, Muhammad Imtiaz
Subsequent Statement of Responsibility
Soliman, Elsayed Z.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
Wake Forest University
Date of Publication, Distribution, etc.
2019
GENERAL NOTES
Text of Note
84 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.S.
Body granting the degree
Wake Forest University
Text preceding or following the note
2019
SUMMARY OR ABSTRACT
Text of Note
In this thesis, we will evaluate the association of metabolically healthy obesity (MHO) and other obesity phenotypes with common electrocardiographic (ECG) markers such as PR interval, P wave duration, QRS duration, and QT interval. In prior studies, MHO has shown inconsistent association with cardiovascular disease (CVD) and mortality compared to metabolically healthy non-obese (MHNO). However, accumulating evidence suggestive of the heightened risk of CVD and mortality with MHO has raised concerns about the existence of truly benign obesity. An examination of the association of obesity phenotypes with ECG markers can give insight into the pathophysiological basis of poor outcomes associated with these phenotypes. We hypothesized that MHO and other obesity phenotypes would be associated with prevalent ECG markers. We performed a cross-sectional analysis of the association of obesity phenotypes with ECG markers in participants from the Third National Health and Nutrition Examination Survey (NHANES-III). The first chapter of this thesis will be a literature review and will discuss the definition, characteristics of MHO and possible reasons for the controversial association of MHO with CVD. We will also discuss possible pathways through which obesity and MetS are associated with ECG abnormalities. The second chapter will be the manuscript of the association of obesity phenotypes with ECG markers. The third chapter is comprised of examination of association of anthropometric measures of abdominal adiposity and overall obesity with ECG markers.