عنوان

Cancer and IgE :

(Number (ISBN

1607614510

(Number (ISBN

9781607614517

Erroneous ISBN

1607614502

Erroneous ISBN

9781607614500

Number

b789725

Title Proper

Cancer and IgE :

General Material Designation

[Book]

Other Title Information

introducing the concept of allergooncology /

First Statement of Responsibility

edited by Manuel L. Penichet, Erika Jensen-Jarolim.

Place of Publication, Distribution, etc.

London :

Name of Publisher, Distributor, etc.

Springer [distributor],

Date of Publication, Distribution, etc.

2010.

Specific Material Designation and Extent of Item

1 online resource (ix, 287 pages) :

Other Physical Details

illustrations (some color)

Text of Note

Includes bibliographical references and index.

Text of Note

Contributors; 1 Introduction; References; 2 The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo; References; 3 The Biology of IgE: The Generation of INTtie; High-Affinity IgE Antibodies; References; 4 Epidemiological Evidence: IgE, Atopy, and Solid Tumors; References; 5 Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies; References; 6 Mast Cells in Allergy and Tumor Disease; References; 7 The IgE Antibody and Its Use in Cancer Immunotherapy; References.

0

Text of Note

Allergies are caused by a person's own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inverse association suggesting a natural role of IgE in cancer immunosurveillance. Is it thus possible that IgE immunoglobulins could have a beneficial function against cancer besides their harmful function in allergy? If so, can we exploit this beneficial function for the development of new cancer therapies? Could oncologists learn from allergists and vice versa? This book attempts to explore step by step these interesting questions, opening a novel science field: AllergoOncology. AllergoOncology by definition aims to reveal the function of IgE-mediated immune responses against cancer cells in order to enhance the understanding of its biology and to develop novel IgE-based treatment options against malignant diseases. Cancer and IgE: Introducing the Concept of AllergoOncology opens new avenues towards IgE antibodies as key effector molecules able to confer protection against cancer development and progression. This affinity-matured class of antibody, belonging to Th2-mediated immunity, uses an exquisite panel of potent effector cells which can eradicate malignant cells. Importantly, IgE is also capable of binding to professional antigen presenting cells thereby enhancing the presentation of cancer antigens and leading to a significant anti-tumor immune response. Based on its anti-tumor efficacy, which has been shown in vitro and in preclinical models, IgE can be potentially used in human in the context passive and active cancer immunotherapy. In summary, this book, which is the first of its class, is a comprehensive volume about the evolving new field AllergoOncology.

Source for Acquisition/Subscription Address

Springer

Stock Number

978-1-60761-450-0

Title

Cancer and IgE.

International Standard Book Number

1607614502

Cancer-- Immunological aspects.

Cancer-- Treatment.

Immunoglobulin E.

Immunotherapy.

Immunoglobulin E.

Immunotherapy.

Neoplasms-- immunology.

Neoplasms-- therapy.

Biomédecine.

Cancer-- Immunological aspects.

Cancer-- Treatment.

HEALTH & FITNESS-- Diseases-- Cancer.

Immunoglobulin E.

Immunotherapy.

MEDICAL-- Oncology.

Sciences de la vie.

HEA-- 039030

MED-- 062000

MJCL

Number

Edition

Class number

Book number

Class number

Class number

Jensen-Jarolim, Erika.

Penichet, Manuel L.

Date of Transaction

20201207030745.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y