عنوان
پدید آورنده
موضوع
رده
RM301.25 .V575 2006eb
RM301
.
25
.
V575
2006eb
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
142946772X
(Number (ISBN
1433701553
(Number (ISBN
1607502194
(Number (ISBN
9781429467728
(Number (ISBN
9781433701559
(Number (ISBN
9781607502197
Erroneous ISBN
158603703X
Erroneous ISBN
9781586037031
NATIONAL BIBLIOGRAPHY NUMBER
Number
b783234
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Virtual ADMET Assessment in Target Selection and Maturation.
General Material Designation
[Book]
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Amsterdam :
Name of Publisher, Distributor, etc.
IOS Press,
Date of Publication, Distribution, etc.
2006.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource (268 pages)
SERIES
Series Title
Solvay Pharmaceuticals Conferences,
Volume Designation
v. 6
ISSN of Series
1566-7685 ;
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index.
CONTENTS NOTE
Text of Note
Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior -- Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces.
Text of Note
Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index.
0
8
SUMMARY OR ABSTRACT
Text of Note
Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods.
ACQUISITION INFORMATION NOTE
Source for Acquisition/Subscription Address
IOS Press
Stock Number
978-1-58603-703-1
OTHER EDITION IN ANOTHER MEDIUM
International Standard Book Number
9781586037031
TOPICAL NAME USED AS SUBJECT
Drug development-- Data processing, Congresses.
Drug development, Congresses.
Computational Biology.
Drug Design.
Pharmaceutical Preparations.
Pharmacokinetics.
Drug development.
MEDICAL-- Drug Guides.
MEDICAL-- Nursing-- Pharmacology.
MEDICAL-- Pharmacology.
MEDICAL-- Pharmacy.
(SUBJECT CATEGORY (Provisional
MED-- 023000
MED-- 058170
MED-- 071000
MED-- 072000
DEWEY DECIMAL CLASSIFICATION
Number
615/
.
190285
LIBRARY OF CONGRESS CLASSIFICATION
Class number
RM301
.
25
.
V575
2006eb
OTHER CLASS NUMBERS
Class number
2008
G-399
Class number
QV
744
Book Number
V818
2006
PERSONAL NAME - PRIMARY RESPONSIBILITY
Testa, B.
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Turski, L.
ORIGINATING SOURCE
Date of Transaction
20201206213752.0
Cataloguing Rules (Descriptive Conventions))
pn
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
