عنوان
پدید آورنده
موضوع
رده
RC271.C5 P7435 2011eb
RC271
.
C5
P7435
2011eb
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
1441973575
(Number (ISBN
1441973583
(Number (ISBN
9781441973573
(Number (ISBN
9781441973580
Erroneous ISBN
9781441973573
NATIONAL BIBLIOGRAPHY NUMBER
Number
b781280
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Principles of anticancer drug development /
General Material Designation
[Book]
First Statement of Responsibility
edited by Manuel Hidalgo [and others].
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
New York :
Name of Publisher, Distributor, etc.
Springer,
Date of Publication, Distribution, etc.
©2011.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource (xvii, 673 pages) :
Other Physical Details
illustrations (some color)
SERIES
Series Title
Cancer Drug Discovery and Development
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index.
CONTENTS NOTE
Text of Note
Principles of Anticancer Drug Development; Blurb; Preface; Contents; Contributors; Part I; Chapter 1: Basic Biostatistics for the Clinical Trialist; 1.1 Introduction; 1.2 Example; 1.3 Aims, Endpoints, and Data Analysis; 1.4 Variable Types; 1.4.1 Continuous Variables; 1.4.2 Categorical Variables; 1.4.3 Time-to-Event Variables; 1.4.4 Variable Transformation; 1.5 Data Description and Displays; 1.5.1 Continuous Variables; 1.5.2 Categorical Variables; 1.5.3 Time-to-Event Variables; 1.5.4 Confidence Intervals; 1.5.5 Confidence Intervals for Means and Differences in Means
Text of Note
1.5.6 Confidence Intervals for Proportions and Comparisons of Proportions1.5.7 Confidence Intervals for Time-to-Event Parameters; 1.6 Hypothesis Testing; 1.6.1 From Research Question to Statistical Hypothesis; 1.6.2 Evaluating Evidence Through p-values; 1.6.3 Types of Errors; 1.7 Common One- and Two-Sample Tests; 1.7.1 Comparing Proportions; 1.7.2 Comparing Means; 1.7.3 The Chi-Square Test; 1.7.4 Fisher's Exact Test; 1.7.5 Testing Paired Data; 1.7.6 Comparing Survival Times; 1.8 How Many Subjects Do I Need?; 1.8.1 Precision-Based Calculations; 1.8.2 Test-Based Calculations
Text of Note
1.9 Multivariable Regression Analyses1.9.1 Logistic Regression; 1.9.2 Cox Proportional Hazards Regression; References; Chapter 2: Fundamental Concepts in Clinical Pharmacology; 2.1 Introduction; 2.2 Glossary; 2.2.1 Pharmacokinetic Terms; 2.2.2 Pharmacodynamic Terms; 2.2.3 Modeling Terms; 2.3 Sampling Schedule and Study Design; 2.4 Patient Numbers and Sampling Intensity; 2.5 What is the Goal of the PK Study?; 2.6 Pharmacokinetics; 2.7 Pharmacokinetic Models; 2.7.1 Compartmental Modeling; 2.7.1.1 One-Compartment Model; 2.7.1.2 Multicompartment Models; 2.7.2 Nonlinear Pharmacokinetics
Text of Note
2.7.3 Noncompartmental Pharmacokinetics2.7.4 Physiologically Based Pharmacokinetic Models; 2.7.5 Population Pharmacokinetics; References; Chapter 3: Bioanalytical Methods in Clinical Drug Development; 3.1 Introduction; 3.2 Methods for Sample Preparation; 3.2.1 Total Drug Measurements; 3.2.1.1 Protein Precipitation; 3.2.1.2 Solid Phase Extraction; 3.2.1.3 Liquid-Liquid Extraction; 3.2.2 Unbound Drug Measurements; 3.2.2.1 Equilibrium Dialysis; 3.2.2.2 Ultrafiltration; 3.2.2.3 Ultracentrifugation; 3.2.2.4 Protein Precipitation; 3.2.2.5 Microdialysis (Extracellular Fluid)
Text of Note
3.3 Methods for Sample Separation3.3.1 Liquid Chromatography; 3.3.1.1 Ultraviolet and Visible Spectroscopy; 3.3.1.2 Fluorescence; 3.3.1.3 Electrical Conductivity; 3.3.1.4 Mass Spectrometry; 3.3.2 Gas Chromatography; 3.3.3 Atomic Spectroscopy; 3.3.3.1 Atomic Absorption Spectroscopy; 3.3.3.2 Inductively Coupled Plasma Mass Spectrometry; 3.4 Validation Requirements; 3.4.1 Range of Reliable Response, Linearity, and Calibration Curves; 3.4.2 Selectivity or Specificity; 3.4.3 Sensitivity; 3.4.4 Accuracy; 3.4.5 Reproducibility; 3.4.6 Stability; 3.4.7 Matrix Effect in LC-MS/MS Based Methods
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SUMMARY OR ABSTRACT
Text of Note
This is a practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
ACQUISITION INFORMATION NOTE
Source for Acquisition/Subscription Address
Springer
Stock Number
978-1-4419-7357-3
OTHER EDITION IN ANOTHER MEDIUM
Title
Principles of anticancer drug development.
TOPICAL NAME USED AS SUBJECT
Antineoplastic agents-- Development.
Cancer-- Treatment.
Drug development.
Antineoplastic Agents-- pharmacokinetics.
Cancer Vaccines-- therapeutic use.
Clinical Trials as Topic.
Neoplasms-- drug therapy.
Antineoplastic agents-- Development.
Cancer-- Treatment.
Drug development.
Médecine.
MEDICAL-- Pharmacology.
(SUBJECT CATEGORY (Provisional
MED-- 071000
DEWEY DECIMAL CLASSIFICATION
Number
615/
.
798
Edition
22
LIBRARY OF CONGRESS CLASSIFICATION
Class number
RC271
.
C5
Class number
RC271
.
C5
Book number
P7435
2011eb
Book number
P75
2011
OTHER CLASS NUMBERS
Class number
2011
C-566
Class number
QV
269
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Hidalgo, Manuel,MD.
ORIGINATING SOURCE
Date of Transaction
20201206200256.0
Cataloguing Rules (Descriptive Conventions))
pn
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
