عنوان

MTOR pathway and mTOR inhibitors in cancer therapy /

(Number (ISBN

1603272704

(Number (ISBN

1603272712

(Number (ISBN

9781603272704

(Number (ISBN

9781603272711

Number

b779464

Title Proper

MTOR pathway and mTOR inhibitors in cancer therapy /

General Material Designation

[Book]

First Statement of Responsibility

Vitaly A. Polunovsky, Peter J. Houghton, editors.

Place of Publication, Distribution, etc.

New York :

Name of Publisher, Distributor, etc.

Humana Press,

Date of Publication, Distribution, etc.

©2010.

Specific Material Designation and Extent of Item

1 online resource (xii, 301 pages)

Series Title

Cancer drug discovery and development

Text of Note

Includes bibliographical references and index.

Text of Note

mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.

0

Text of Note

MTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment - targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. In this work, experts in TOR signaling have contributed in two thematic areas: mTOR Signaling and Cancer Therapy (chapters 1 - 8) and Therapeutic Targeting Downstream of mTOR (chapter 9 - 13). All chapters of mTOR Pathway and mTOR Inhibitors in Cancer Therapy are completely new or have been extensively updated by their authors; and we are indebted to all authors who have exemplified the links between these 2 thematic areas.

Source for Acquisition/Subscription Address

Springer

Stock Number

978-1-60327-270-4

Title

MTOR pathway and mTOR inhibitors in cancer therapy.

International Standard Book Number

9781603272704

Cancer-- Treatment.

Antineoplastic Agents-- therapeutic use.

Enzyme Inhibitors-- therapeutic use.

Neoplasms-- drug therapy.

Protein-Serine-Threonine Kinases-- therapeutic use.

Cancer-- Treatment.

HEALTH & FITNESS-- Diseases-- Cancer.

Médecine.

MEDICAL-- Oncology.

HEA-- 039030

MED-- 062000

Number

Edition

Class number

Book number

Class number

Class number

Houghton, Peter J.

Polunovskiĭ, V. A., (Vitaliĭ Aleksandrovich)

Date of Transaction

20201206183357.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y