عنوان

Target discovery and validation :

(Number (ISBN

1588296563

(Number (ISBN

1588298906

(Number (ISBN

1597451657

(Number (ISBN

1597452084

(Number (ISBN

9781588296566

(Number (ISBN

9781588296566

(Number (ISBN

9781588298904

(Number (ISBN

9781597451659

(Number (ISBN

9781597452083

Number

b764751

Title Proper

Target discovery and validation :

General Material Designation

[Book]

Other Title Information

reviews and protocols /

First Statement of Responsibility

edited by Mouldy Sioud.

Place of Publication, Distribution, etc.

Totowa, N.J. :

Name of Publisher, Distributor, etc.

Humana Press,

Date of Publication, Distribution, etc.

©2007.

Specific Material Designation and Extent of Item

1 online resource (2 volumes) :

Other Physical Details

illustrations

Series Title

Methods in molecular biology,

Volume Designation

360-361

ISSN of Series

1064-3745 ;

Text of Note

Includes bibliographical references and indexes.

Text of Note

V. 1. Emerging strategies for targets and biomarker discovery -- v. 2. Emerging molecular targets and treatment options -- v. 2. Emerging molecular targets and treatment options.

0

Text of Note

Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products. Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic. Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.

Title

Target discovery and validation.

International Standard Book Number

1588296563

Biochemical markers-- Therapeutic use.

DNA microarrays.

Drug targeting.

Drugs-- Design.

Molecular pharmacology.

Tumor markers.

Antineoplastic Agents.

Biomarkers, Tumor.

Drug Design.

Marqueurs biologiques-- Emploi en thérapeutique.

Marqueurs tumoraux.

Médicaments-- Ciblage.

Médicaments-- Conception.

Pharmacologie moléculaire.

Puces à ADN.

Antineoplastic agents.

Biochemical markers-- Therapeutic use.

DNA microarrays.

DNA microarrays.

Drug Design.

Drug targeting.

Drug targeting.

Drugs-- Design.

Drugs-- Design.

HEALTH & FITNESS-- Diseases-- Cancer.

MEDICAL-- Oncology.

Molecular pharmacology.

Molecular pharmacology.

Tumor Markers, Biological.

Tumor markers.

Tumor markers.

HEA-- 039030

MED-- 062000

Number

Edition

Class number

Book number

Class number

Class number

Class number

Book Number

Book Number

System Code

Sioud, Mouldy.

Date of Transaction

20201206102458.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y