Preface Short Communication Biological complexity by natural selection and self-organization: a game of survival (C. Hui, Centre of Excellence for Invasion Biology, Department of Conservation Ecology and Entomology, University of Stellenbosch, South Africa) Research and Review Studies Epidemiological Modeling for the Real World (David P. Wilson, National Centre in HIV Epidemiology and Clinical Research, Faculty of Medicine, University of New South Wales, Australia) Structure-dynamics relationships of metabolic networks: The susceptibility-responsivity connection of enzymes (Antonio S. Torralba, Department of Physics and Astronomy, University College London, UK) Haptotaxis in Pre-necrotic Avascular Tumours (D.G. Mallet, G.J. Pettet, School of Mathematical Sciences, Queensland University of Technology) Mathematical Anaylsis of a Cholera Model with Carriers: Assessing the Effects of Treatment (Z. Mukandavire, Department of Applied Mathematics, National University of Science and Technology, Zimbabwe) Mathematical Models and Parameter Estimation for Heterogeneous Cell Population Dynamics (Gennady Bocharov, Institute of Numerical Mathematics, Russia, Tatyana Luzyanina, Institute of Mathematical Problems in Biology, Russia, Dirk Roose, Department of Computer Science, Katholieke Universiteit Leuven, Belgium) Immuno-Epidemiology and HIV/AIDS: A Modeling Prospective (Swati DebRoy and Maia Martcheva, Department of Mathematics, University of Florida, FL) Mathematical Models of Particle Deposition and Bronchial Clearence in the Human Respiratory Tract -- A Review (Robert Sturm, University of Salzburg, Department of Materials Engineering and Physics, Austria) Systems Biology of the Tryptophan Operon (M. Santillan, Unidad Monterrey, Centro de Investigacion y Estudios Avanzados del IPN, Mexico, Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University, Canada, Eduardo S. Zeron, Departamento de Matematicas, Mexico, M.C. Mackey, Centre for Nonlinear Dynamics.