Front Cover; Advances in Clinical Chemistry; Copyright Page; Contents; Contributors; Preface; Chapter 1. The Biochemistry of Aging; 1. Introduction; 2. Life Expectancy versus Maximum Life Span; 3. Theories of Aging; 4. Support for Free Radical Theory; 5. Magnesium, Zinc, and Selenium.; 6. Heat Shock Proteins; 7. Age-Associated Diseases/Disorders; 8. Summary; References; Chapter 2. Cystatin C-Properties and Use as Diagnostic Marker; 1. Protease-Antiprotease Equilibria; 2. Biological Roles of Papain-like Cysteine Proteases
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2. Cytokines and Other Factors3. Regulation of the Apoptosis of Osteoclasts; 4. Hormones; 5. Proinsulin, Insulin, Insulin-like Growth Factors (IGF), IGF-Binding Proteins, and Changes in Bone Metabolism in Diabetes Mellitus; 6. Biochemical Markers of the Metabolism of Bone Tissue; References; Chapter 6. Laboratory Markers of Ovarian Function; 1. Introduction; 2. Age; 3. Basal Hormone Levels; 4. Function of the Pituitary-Ovarian Axis; 5. Follicular Fluid; 6. Granulosa Cells; 7. Quality of Embryos; 8. Hormone Levels after Embryo Transplant; 9. Discussion and Conclusion; References; Index
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3. The Cystatin Superfamily of Inhibitors of Papain-like Cysteine Proteases4. The Human Cystatins; 5. Identification of Target Enzymes for Cystatins; 6. Distribution of Cystatins in Body Fluids; 7. Additional Functions Attributed to Cystatin C; 8. Previous Designations for Cystatin C; 9. Structure of Human Cystatin C and Its Concentration in Body Fluids; 10. Serum/Plasma Cystatin C as a Marker for Glomerular Filtration Rate (GFR); 11. Urine Cystatin C as a Marker for Proximal Tubular Damage; 12. Cystatin C and Cerebral Hemorrhage; References
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Chapter 3. The Role of Receptors In Prostate Cancer1. Introduction; 2. Androgen Receptors; 3. Estrogen Receptors and Other Cytoplasmic/Nuclear Receptors; 4. Growth Factor Receptors; 5. Other Membrane Receptors; 6. Conclusion; References; Chapter 4. Oxidative Modifications of Protein Structures; 1. Sources of Reactive Oxygen Species; 2. Oxidative Modifications of Protein Structures; 3. Biological Effects of Protein Oxidation; 4. Detection of Oxidatively Modified Proteins in a Clinical Laboratory; References; Chapter 5. Selected Markers of Bone Biochemistry; 1. Introduction
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SUMMARY OR ABSTRACT
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For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology, informatics, and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.