Front Cover; Advances in Immunology, Volume 42; Copyright Page; Contents; Chapter 1. The Clonotype Repertoire of B Cell Subpopulations; I. Introduction; II. The Mechanics of Variable Region Gene Expression; III. Unresolved Issues Concerning V Region Expression; IV. The Relative Role of Random Somatic Events versus Evolutionary Selection in V Region Expression; V. The Impact of Environment on Primary B Cell Repertoire Expression; VI. The Relationship of B Cell Repertoire Expression and B Cell Subpopulations; VII. Conclusions; References.
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Chapter 2. The Molecular Genetics of the Arsonate Idiotypic System of A/J MiceI. Introduction; II. The Arsonate System; III. Molecular Genetics of the Ars A Heavy Chain; IV. The Ars A VH Gene Segment as a Probe into the J558 VH Gene; V. Organization of the Murine VH Complex; VI. Molecular Genetics of the Ars A Light Chain; VII. Serologic and Structural Analyses of Ab2 Antibodies in the Arsonate System; VIII. Conclusions; References; Chapter 3. The Interleukin 2 Receptor; I. Introduction; II. IL-2 Receptor Structure.
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I. IntroductionII. Etiology; III. Diagnosis; IV. Pathology; V. Therapy; VI. Prospects; References; Chapter 7. Alterations of the Immune System in Ulcerative Colitis and Crohn's Disease; I. Introduction; II. Genetic Markers; III. Alterations of Peripheral Blood Lymphocyte Function in IBD; IV. Serum Antibodies and DR Antigens; V. Cell-Mediated Cytotoxicity; VI. Immunopathology of IBD; VII. Immunoregulatory Alterations; VIII. Antibody Secretion; IX. Granulocyte Function; X. Products of the Complement Pathway; XI. Prostaglandins and Leukotrienes; XII. Immunopharmacology.
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III. IL-2 Binding Characteristics Based on the a, ß Heterodimer Receptor StructureIV. aChains Transduce the Growth Signal; V. The Regulation of IL-2 Receptor Expression; VI. The Functional Consequences of the Noncovalent Biomolecular IL-2 Receptor Structure; VII. Conclusions; References; Chapter 4. Characterization of Functional Surface Structures on Human Natural Killer Cells; I. Introduction; II. Clonal Human NK Cell Lines; III. NK Cell Phenotype; IV. Antigens Involved in NK Effector-Target Cell Interactions; V. Target Antigen for NKH1+CD3+NKTa+ Clones-TNK TAR.
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VI. Rearrangement and Expression of T Cell Receptor Genes in NK CellsVII. Summary; References; Chapter 5. The Common Mediator of Shock, Cachexia, and Tumor Necrosis; I. Introduction; II. The Dual Nature of Cachectin (TNF); III. The Structure of Cachectin/TNF; IV. Toxic Effects of Cachectin; V. Cachectin Biosynthesis: Cellular Source, Inducing Stimuli, and Kinetics of Synthesis and Release; VI. The Effects of Cachectin on Various Cells and Tissues; VII. Characterization of the Cachectin Receptor; VIII. The Beneficial Effect of Cachectin; References; Chapter 6. Myasthenia Gravis.