عنوان

From enzyme models to model enzymes /

(Number (ISBN

1847559786

(Number (ISBN

9781847559784

Erroneous ISBN

0854041753

Erroneous ISBN

9780854041756

Number

b717251

Title Proper

From enzyme models to model enzymes /

General Material Designation

[Book]

First Statement of Responsibility

Anthony J. Kirby, Florian Hollfelder.

Place of Publication, Distribution, etc.

Cambridge, UK :

Name of Publisher, Distributor, etc.

Royal Society of Chemistry,

Date of Publication, Distribution, etc.

©2009.

Specific Material Designation and Extent of Item

1 online resource (xi, 273 pages) :

Other Physical Details

illustrations (some color)

Text of Note

Includes bibliographical references and index.

Text of Note

From models through mimics to artificial enzymes -- Evaluation of catalytic efficiency in enzymes and enzyme models -- Constructing enzyme models: building up complexity -- Enzyme models classified by reaction -- Design vs. iterative methods: mimicking the way nature generates catalysts.

0

Text of Note

"Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is one of the great challenges facing science today. Our current level of understanding fails the basic, practical test - designing and making artificial systems with catalytic efficiencies to rival those of natural enzymes. Chemists and bio-scientists are well aware of this problem, and 'artificial enzymes' have been a 'hot topic' for many years. However, until now, there has been no book devoted specifically to this subject. This is the first book to provide a critical introduction to, and overview of, this exciting area. It is aimed at students and more senior researchers with specialist or general interests in the field. The book starts with a systematic overview of the most important properties of natural enzymes, with special emphasis on mechanisms and efficiency of catalysis. This is followed by a summary of the mechanisms involved in the major classes of reaction they catalyze, and spells out the logical progression from simple mechanistic models for particular reactions to the first, rudimentary artificial enzymes catalyzing them. Catalytic efficiency is the key criterion for inclusion. An analysis of the strengths and limitations of the classical design-based approach to catalysis by enzyme mimics leads on to a discussion of recent advances which use selection methods coupled with iterative techniques for creating and improving catalysts by natural methods. The comparison of natural and artificial catalysts requires a quantitative understanding based on the interpretation of kinetic measurements. Key skills in data interpretation are introduced in a guided approach that connects the formal treatment of kinetic measurements with their chemical and biological interpretation."--Publisher's description.

Source for Acquisition/Subscription Address

Royal Society of Chemistry

Stock Number

T3023

Title

From enzyme models to model enzymes.

International Standard Book Number

9780854041756

Enzymes-- Synthesis.

Enzymes.

Chemistry.

-Enzym

Enzymes-- Synthesis.

Enzymes.

Enzymkatalyse

Modell

SCIENCE-- Life Sciences-- Biochemistry.

PN

PSBZ

SCI

SCI-- 007000

Number

Edition

Class number

Book number

Kirby, Anthony J., (Anthony John),1935-

Hollfelder, Florian.

Date of Transaction

20201208093605.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y