Overview of biological mechanism of aging / Vincent J. Cristofalo -- Genetic diseases of premature aging as models of senescence / W. Ted Brown -- Growth factors and cell aging / Paul D. Phillips, David L. Doggett, and Vincent J. Cristofalo -- Role of endogenous proteins as negative growth modulators during in vitro cellular aging of human diploid fibroblasts / Mary Beth Porter and James R. Smith -- T-Cell function in aging: mechanisms of decline / Donna M. Murasko and I. Michael Goonewardene -- Molecular genetic approaches to mechanisms of senescence / Samuel Goldstein -- Altered protein metabolism in aging / Ari Gafni -- Mechanisms of altered hormone-neurotransmitter action during aging: from receptors to calcium mobilization / George S. Roth -- Skeletal muscle weakness and fatigue in old age: underlying mechanisms / John A. Faulkner, Susan V. Brooks, and Eileen Zerba -- Vulnerability of neuronal cytoskeleton in aging and Alzheimer disease: widespread involvement of all three major filament systems / J.Q. Trojanowski [and others] -- Dietary restriction as a probe of mechanisms of senescence / Edward J. Masoro and Roger J.M. McCarter -- Role of free radicals in senescence / R.G. Allen.