COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction.
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SUMMARY OR ABSTRACT
Text of Note
In silico modeling for toxicology provides effective pre-screening for chemicals in pharmaceutical discovery and the environment. This work discusses the validation of such models for regulatory purposes, the validation criteria, and other requirements for regulatory acceptance. It also looks at QSAR models, environmental modeling, among others.