عنوان

Ligand-macromolecular interactions in drug discovery :

(Number (ISBN

1607612445

(Number (ISBN

9781607612445

Erroneous ISBN

1607612437

Erroneous ISBN

9781607612438

Number

b700600

Title Proper

Ligand-macromolecular interactions in drug discovery :

General Material Designation

[Book]

Other Title Information

methods and protocols /

First Statement of Responsibility

edited by Ana Cećilia A. Roque.

Place of Publication, Distribution, etc.

New York, NY :

Name of Publisher, Distributor, etc.

Humana Press,

Date of Publication, Distribution, etc.

©2010.

Specific Material Designation and Extent of Item

1 online resource (x, 297 pages) :

Other Physical Details

illustrations

Series Title

Methods in molecular biology,

Series Title

Springer protocols

Volume Designation

572

ISSN of Series

1064-3745 ;

Text of Note

Includes bibliographical references and index.

Text of Note

Part I. Reviews -- 1. An Historical overview of drug discovery / Ana Sofia Pina, Abid Hussain, and Ana Cecília Roque -- 2. Ligand mcromolecule iteractions : theoretical principles of molecular recognition / Tammy Nolan, Nidhi Singh, and Christopher R. McCurdy -- 3. X-Ray cystallography in drug discovery / Ana Luísa Carvalho, José Trincão, and Maria João Romão -- 4. Virtual screening of compound libraries / Nuno M.F.S.A. Cerqueira, Sérgio F. Sousa, Pedro A. Fernandes, and Maria João Ramos -- Part II: Protocols -- 5. Combinatorial chemistry and the synthesis of compound libraries / Rolf Breinbauer and Matthias Mentel -- 6. Ligand-based nuclear magnetic resonance screening techniques / Aldino Viegas, Anjos L. Macedo, and Eurico Cabrita -- 7. Isothermal titration calorimetry and differential scanning calorimetry / Geoff Holdgate -- 8. Adaptive combinatorial design of focused compound libraries / Gisbert Schneider and Andreas Schüller -- 9. Chemical microarrays : a new tool for discovery enzyme inhibitors / Shuguang Liang, Wei Xu, Kurumi Y. Horiuchi, Yuan Wang, and Haiching Ma -- 10. Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays / Kurumi Y. Horiuchi and Haiching Ma -- 11. Small molecule protein interaction profiling with functional protein microarrays / Lihao Meng, Dawn Mattoon, and Paul Predki -- 12. Capillary electrophoresis in drug discovery / Milena Quaglia and Ersilia De Lorenzi -- 13. SPR in drug discovery : searching bioactive compounds in plant extracts / Maria Minunni and Anna Rita Bilia -- 14. Application of frontal affinity chromatography with mass spectrometry (FAC-MS) for stereospecific ligand-macromolecule interaction, detection and screening / Jacek Slon-Usakiewicz and Peter Redden -- 15. GPC spin column HPLC-ESI-MS methods for screening drugs noncovalently bound to proteins / Marshall M. Siegel -- 16. A scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening / Yuren Wang and Philip Jones -- 17. A natural products approach to drug discovery : probing modes of action of antitumor agents by genome-scale cDNA library screening / Hendrik Luesch and Pedro Abreu -- 18. Ligand-macromolecule interactions in live cells by fluorescence correlation spectroscopy / Aladdin Pramanik.

0

Text of Note

Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead compounds, and further characterization, screening, and assays for therapeutic efficacy and toxicity. In Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds, either natural or synthetic, and complementary biological targets, within the scope of drug discovery. Beginning with a historical perspective of drug research focusing on the contribution of genomics, proteomics, high-throughput methods, and computational developments in drug discovery, the book then delves into highly detailed methods on topics such as NMR spectroscopy, compound library design and synthesis, chemical and biological microarrays, and many others. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols will serve as an ideal guide to scientists in academia and in industry who are striving to further our knowledge of medicines.

Source for Acquisition/Subscription Address

Springer

Stock Number

978-1-60761-243-8

Title

Ligand-macromolecular interactions in drug discovery.

International Standard Book Number

9781607612438

Drug development.

Ligand binding (Biochemistry)

Macromolecules.

Analytical, Diagnostic and Therapeutic Techniques and Equipment

Biological Science Disciplines.

Chemical Actions and Uses

Chemicals and Drugs

Chemistry, Pharmaceutical.

Chemistry.

Clinical Laboratory Techniques.

Disciplines and Occupations

Drug Discovery.

Investigative Techniques

Laboratory Chemicals.

Ligands.

Macromolecular Substances.

Natural Science Disciplines.

Pharmacology.

Specialty Uses of Chemicals

Drug development.

Health & Biological Sciences.

Ligand binding (Biochemistry)

Macromolecules.

Pharmacy, Therapeutics, & Pharmacology.

MED071000

MMG

Number

Edition

Class number

Book number

Class number

Class number

Book Number

Roque, Ana Cecília A., (Ana Cecília Afonso)

Date of Transaction

20201207162410.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y