عنوان

Sustained Attention in Adult Mice is Modulated by Prenatal Choline Availability

Number

LA2d4086s1

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Sustained Attention in Adult Mice is Modulated by Prenatal Choline Availability

General Material Designation

[Article]

First Statement of Responsibility

Mohler, Eric G.; Meck, Warren H.; Williams, Christina L.

Text of Note

Our laboratory has discovered that alterations in choline availability to the developing rat fetus lead to long-term changes in spatial and temporal memory function across the lifespan and associated changes in the septo-hippocamal system. The current study was undertaken to determine if performance on an attention task, believed to be relatively independent of septo-hippocampal function, was modified by changes in choline availability prior to birth. A sustained attention task was developed for mice that includes all the features of the 2-choice signal-detection procedure initially applied to rats (McGaughy & Sarter, 1995). Prenatal choline deficiency significantly impaired the ability of adult mice to sustain attention to a brief visual cue throughout a session as evidenced by decreased "Hits" and increased "Omissions" during the second-half of trials. In contrast, prenatal choline supplementation enhanced the ability of mice to detect visual cues but did not alter their ability to maintain attention throughout a session. These data support the view that the effects of alterations in choline availability on brain anatomy, physiology, and function likely extend beyond the septo-hippocampal system that modulates spatial memory. In the case of the sustained attention task, this likely includes cholinergic projections from the basal forebrain to neocortex.

Date of Publication

2001

Title

International Journal of Comparative Psychology

Volume Number

14/3

Entry Element

Mohler, Eric G.; Meck, Warren H.; Williams, Christina L.

Electronic name

[Article]

275578

a

Y