A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage
General Material Designation
[Article]
First Statement of Responsibility
Lederhandler, M; Chen, L; Meehan, SA; Brinster, NK; Neimann, A
SUMMARY OR ABSTRACT
Text of Note
Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars. Porphyria cutanea tarda occurs in relation to inhibition of uroporphyrinogen decarboxylase, a key enzyme in the heme biosynthesis pathway. A number of genetic and acquired factors increase susceptibility to PCT by reducing uroporphyrinogen decarboxylase activity. A handful of other vesiculobullous conditions may mimic PCT both clinically and histologically; therefore, both skin biopsy and laboratory evaluation are helpful in confirming the diagnosis. We report a case of PCT in the setting of cigarette usage and untreated hepatitis C infection.
SET
Date of Publication
2019
Title
Dermatology Online Journal
Volume Number
25/12
PERSONAL NAME - PRIMARY RESPONSIBILITY
Entry Element
Lederhandler, M; Chen, L; Meehan, SA; Brinster, NK; Neimann, A