Safety of guselkumab in hepatitis B virus infection
General Material Designation
[Article]
First Statement of Responsibility
Duncan, James Robert; Orlowski, Timothy J.; Elewski, Boni E.
SUMMARY OR ABSTRACT
Text of Note
Reactivation of hepatitis B virus (HBV) following the use of TNF antagonists has been reported and is a contraindication to use of these medications. Although the risk of reactivation of HBV during use of ustekinumab and secukinumab is low in patients with only HBV core antibody positivity, the risk is substantial in patients with chronic HBV infection. Less information is available regarding the use of pure IL-23 antagonists. Herein we discuss the successful treatment with guselkumab of a patient with HBV core antibody positivity, without evidence of HBV reactivation or other liver complications.
SET
Date of Publication
2019
Title
Dermatology Online Journal
Volume Number
25/10
PERSONAL NAME - PRIMARY RESPONSIBILITY
Entry Element
Duncan, James Robert; Orlowski, Timothy J.; Elewski, Boni E.