عنوان

Topical treatment of melanoma skin metastases with Imiquimod: a review

Number

LA8rj4k7r6

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Topical treatment of melanoma skin metastases with Imiquimod: a review

General Material Designation

[Article]

First Statement of Responsibility

Sisti, Andrea; Sisti, Giovanni; Oranges, Carlo Maria

Text of Note

Background: At present, case studies are the only source of results on imiquimod (IMQ) as monotherapy in cutaneous metastases from melanoma. We analyzed these studies in the literature with the aim to review the efficacy of IMQ as topical treatment for melanoma skin metastases. Objective: The aim of our review was to critically assess the studies evaluating the monotherapy with IMQ cream in the treatment of cutaneous metastases from melanoma.  Methods: A PubMed search was conducted using the term ''melanoma'' combined with ''metastases'' and ''imiquimod''. Results: 57 studies were identified. 46 did not meet inclusion criteria, leaving 11 case studies. Overall, 17 patients were treated in these 11 studies. Main treatment choice was 5% IMQ cream applied once daily (for 6-8 hours), five days per week under occlusive conditions, in 8/17 patients (47,1%). IMQ was applied 3 times weekly in 4/17 patients (23,53%), daily in 2/17 patients (11,76%) and twice daily in 2/17 patients (11,76%).

Date of Publication

2015

Title

Dermatology Online Journal

Volume Number

21/2

Entry Element

Sisti, Andrea; Sisti, Giovanni; Oranges, Carlo Maria

Electronic name

[Article]

275578

a

Y