Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease
General Material Designation
[Article]
First Statement of Responsibility
Balagula, Yevgeniy; Taube, Janis M; Wang, Timothy; Dorafshar, Amir H; Sweren, Ronald J
SUMMARY OR ABSTRACT
Text of Note
Numerous complications can be observed in the post-transplant period among recipients of hematopoietic stem cells including graft-versus-host disease (GVHD), which is associated with significant morbidity and mortality. On the other hand, graft versus tumor (GVT) effect is a well-described phenomenon in patients with hematologic malignancies and has also been reported in renal cell cancer, ovarian cancer, breast carcinoma, and melanoma. We describe spontaneous regression of a cutaneous invasive squamous cell carcinoma and multifocal atypical intraepidermal proliferations in a patient with chronic graft-versus-host disease following initiation of extracorporeal photopheresis (ECP). This observation raises questions regarding the GVT in cutaneous neoplasms and potential immunomodulatory effects of ECP.
SET
Date of Publication
2014
Title
Dermatology Online Journal
Volume Number
20/5
PERSONAL NAME - PRIMARY RESPONSIBILITY
Entry Element
Balagula, Yevgeniy; Taube, Janis M; Wang, Timothy; Dorafshar, Amir H; Sweren, Ronald J