Cetirizine-induced Acute Generalized Exanthematous Pustulosis: a serious reaction to a commonly used drug
General Material Designation
[Article]
First Statement of Responsibility
Badawi, Ahmed H; Tefft, Kimberly; Fraga, Garth R; Liu, Deede Y
SUMMARY OR ABSTRACT
Text of Note
Acute generalized exanthematous pustulosis (AGEP) is an abrupt cutaneous adverse reaction usually in response to medications. It is generally a self-limiting disease if diagnosed promptly and the offending agent discontinued. Cetirizine, a commonly used anti-histamine medication for the treatment of allergic diseases has few reported side effects and is normally well-tolerated and effective. Herein, the first reported case of cetirizine induced AGEP is presented, followed by a discussion of the clinical and pathological aspects of this adverse cutaneous reaction to a widely used drug. Awareness of this reaction is vital owing to the extensive use of cetirizine and the importance of drug cessation once the reaction is identified. Lastly, other pustular cutaneous reactions may present similarly and therefore accurate identification of this disease can prevent unnecessary diagnostic testing.
SET
Date of Publication
2014
Title
Dermatology Online Journal
Volume Number
20/5
PERSONAL NAME - PRIMARY RESPONSIBILITY
Entry Element
Badawi, Ahmed H; Tefft, Kimberly; Fraga, Garth R; Liu, Deede Y