عنوان

Eruption of squamous cell carcinomas after beginning nilotinib therapy

Number

LA35b1q4vf

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Eruption of squamous cell carcinomas after beginning nilotinib therapy

General Material Designation

[Article]

First Statement of Responsibility

Crain, Caroline B; Winsett, Frank T; Woolridge, Katelyn F; Wilson, Janice M; Goodwin, Brandon P

Text of Note

Chronic myelogenous leukemia (CML) is characterized by a reciprocal translocation between the long arms of chromosomes 9 and 22 leading to the formation of a constitutively active tyrosine kinase. Tyrosine kinase inhibitors (TKIs) are the treatment of choice for patients diagnosed with CML and have many associated side effects including the rarely-reported eruption of squamous cell carcinomas (SCCs). Herein, we report a patient with CML who presented with sudden onset of multiple scaly lesions on his legs and trunk after beginning treatment with nilotinib, a novel TKI. Six biopsies were performed at his initial presentation and four of these lesions were confirmed to be keratoacanthoma-type SCCs. One month later, the patient reported the development of multiple new similar lesions on his legs, arms, and face. Four more biopsies were performed revealing keratoacanthoma-type and well-differentiated SCCs. Certain tyrosine kinase inhibitors such as sorafenib and quizartinib have been reported to cause eruptive keratoacanthoma (KA)-type SCCs as seen in our patient. However, there is only one other report in the literature of nilotinib promoting the development of SCCs or KAs. Physicians should be aware of this potential adverse effect and patients taking nilotinib should be closely monitored by a dermatologist.

Date of Publication

2020

Title

Dermatology Online Journal

Volume Number

26/6

Entry Element

Crain, Caroline B; Winsett, Frank T; Woolridge, Katelyn F; Wilson, Janice M; Goodwin, Brandon P

Electronic name

[Article]

275578

a

Y