The dissertation critically examines the process of discovery, thought and language at the frontier of modern science. It is based on two and a half years of ethnographic research at the particle accelerator complex, the Large Hadron Collider (LHC) at CERN, Switzerland. In March 2010, the LHC began the world's highest energy experiments as a probe into the structure of matter and forces of nature. In the light of the LHC experiments, the dissertation investigates the relation of general beliefs and technical procedures of science with the principles of classification of knowledge, to show how they conjointly constitute a specific cultural or symbolic mode of apprehending the world, and to inquire how this mode is expressed, affirmed and maintained in everyday behavior. Dwelling amongst the particle physics community at CERN, I observed that conceptions of matter and energy were derived from submerged assumptions about how the universe works. These assumptions took the form of proscriptions and dualisms: values do not affect physical reality, the mind does not participate in the universe, or conventions do not impinge on laws of physics. In spite of this, and perhaps more interesting, I found a few puzzling concepts in specific data-sets of theory, experiment and instrumentation, that confront and challenge, quite effectively to my mind, the separations of subject and object, or sign and thing, in a discipline that ostensibly proceeds from their strict separation.