عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
LA5327529f
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Roles of planar cell polarity pathways in the development of neutral tube defects
General Material Designation
[Article]
First Statement of Responsibility
Wu, Gang; Huang, Xupei; Hua, Yimin; Mu, Dezhi
SUMMARY OR ABSTRACT
Text of Note
Abstract Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many advances in the understanding of NTDs and the identification of many genes related to NTDs, the fundamental etiology for the majority of cases of NTDs remains unclear. Planar cell polarity (PCP) signaling pathway, which is important for polarized cell movement (such as cell migration) and organ morphogenesis through the activation of cytoskeletal pathways, has been shown to play multiple roles during neural tube closure. The disrupted function of PCP pathway is connected with some NTDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of NTDs.
SET
Date of Publication
2011
Title
UCSF
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Article]
275578
a
Y
