عنوان

Early-life exposure to PM2.5 and risk of acute asthma clinical encounters among children in Massachusetts:

Number

LA2pf1k8n0

Title Proper

Early-life exposure to PM2.5 and risk of acute asthma clinical encounters among children in Massachusetts:

General Material Designation

[Article]

First Statement of Responsibility

Khalili, RoxanaBartell, Scott MHu, XuefeiLiu, YangChang, Howard HBelanoff, CandiceStrickland, Matthew JVieira, Verónica M

Title Proper by Another Author

a case-crossover analysis.

Text of Note

BACKGROUND:Associations between ambient particulate matter < 2.5 μm (PM2.5) and asthma morbidity have been suggested in previous epidemiologic studies but results are inconsistent for areas with lower PM2.5 levels. We estimated the associations between early-life short-term PM2.5 exposure and the risk of asthma or wheeze clinical encounters among Massachusetts children in the innovative Pregnancy to Early Life Longitudinal (PELL) cohort data linkage system. METHODS:We used a semi-bidirectional case-crossover study design with short-term exposure lags for asthma exacerbation using data from the PELL system. Cases included children up to 9 years of age who had a hospitalization, observational stay, or emergency department visit for asthma or wheeze between January 2001 and September 2009 (n = 33,387). Daily PM2.5 concentrations were estimated at a 4-km resolution using satellite remote sensing, land use, and meteorological data. We applied conditional logistic regression models to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CI). We also stratified by potential effect modifiers. RESULTS:The median PM2.5 concentration among participants was 7.8 μg/m3 with an interquartile range of 5.9 μg/m3. Overall, associations between PM2.5 exposure and asthma clinical encounters among children at lags 0, 1 and 2 were close to the null value of OR = 1.0. Evidence of effect modification was observed by birthweight for lags 0, 1 and 2 (p < 0.05), and season of clinical encounter for lags 0 and 1 (p < 0.05). Children with low birthweight (LBW) (< 2500 g) had increased odds of having an asthma clinical encounter due to higher PM2.5 exposure for lag 1 (OR: 1.08 per interquartile range (IQR) increase in PM2.5; 95% CI: 1.01, 1.15). CONCLUSION:Asthma or wheeze exacerbations among LBW children were associated with short-term increases in PM2.5 concentrations at low levels in Massachusetts.

Date of Publication

2018

Title

UC Irvine

Electronic name

[Article]

277932

a

Y